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Meta-analysis and systematic review of peripheral platelet-associated biomarkers to explore the pathophysiology of alzheimer's disease
IntroductionPlatelets are the primary peripheral reserve of amyloid precursor protein (APP), providing more than 90% of blood amyloid-beta (Aβ). Some...
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Data-driven causal model discovery and personalized prediction in Alzheimer's disease
With the explosive growth of biomarker data in Alzheimer’s disease (AD) clinical trials, numerous mathematical models have been developed to...
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Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities
Dementia with Lewy bodies is the second most common cause of neurodegenerative dementia after Alzheimer's disease. Dementia with Lewy bodies can...
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Effect of Letrozole on hippocampal Let-7 microRNAs and their correlation with working memory and phosphorylated Tau protein in an Alzheimer's disease-like rat model
BackgroundLet-7 microRNAs (miRNAs) may contribute to neurodegeneration, including Alzheimer's disease (AD), but, they were not investigated in...
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Design of a seniors and Alzheimer's disease caring service platform
BackgroundTo meet the needs of aging and dementia patients in Taiwan, this study designed a nursing system that includes communication, location...
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Plasma repressor element 1-silencing transcription factor levels are decreased in patients with Alzheimer's disease
BackgroundRepressor element 1-silencing transcription (REST)/neuron-restrictive silencer factor is considered a new therapeutic target for...
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Predicting mild cognitive impairment progression to Alzheimer’s disease based on machine learning analysis of cortical morphological features
PurposeTo establish a model for predicting mild cognitive impairment (MCI) progression to Alzheimer's disease (AD) using morphological features...
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Undergraduate nursing students’ knowledge of and attitudes toward people with alzheimer’s disease
As the population ages, the number of people living with Alzheimer's disease is expected to grow; consequently, nursing students are expected to care...
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Amyloid-Lowering Monoclonal Antibodies for the Treatment of Early Alzheimer’s Disease
Alzheimer's disease (AD) is the leading cause of dementia worldwide. Numerous biomarker studies have clearly demonstrated that AD has a long...
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French cross-cultural adaptation and validation of the Quality of Life-Alzheimer's Disease scale in Nursing Homes (QOL-AD NH)
BackgroundNo specific scale to measure Quality of Life in Alzheimer's Disease in Nursing Homes (QoL-AD NH) exists in French. We aimed to translate...
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Ischemic heart disease-related mortality in Brazil, 2006 to 2020. A study of multiple causes of death
ContextBoth the aging of the population and the increase in noncommunicable diseases may influence the progression and outcomes culminating in death,...
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NREM sleep as a novel protective cognitive reserve factor in the face of Alzheimer's disease pathology
BackgroundAlzheimer’s disease (AD) pathology impairs cognitive function. Yet some individuals with high amounts of AD pathology suffer marked memory...
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Causal relationships between type 1 diabetes mellitus and Alzheimer’s disease and Parkinson’s disease: a bidirectional two-sample Mendelian randomization study
BackgroundPrevious compelling evidence suggests an association between Type 2 diabetes (T2D) and neurodegenerative diseases. However, it remains...
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Comparative Efficacy and Safety of Monoclonal Antibodies for Cognitive Decline in Patients with Alzheimer’s Disease: A Systematic Review and Network Meta-Analysis
BackgroundRecent clinical trials of anti-Aβ monoclonal antibodies (mAbs) in the treatment of early Alzheimer’s disease (AD) have produced encouraging...
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Automated Medical Diagnosis of Alzheimer´s Disease Using an Efficient Net Convolutional Neural Network
Alzheimer's disease (AD) poses an enormous challenge to modern healthcare. Since 2017, researchers have been using deep learning (DL) models for the...
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Causal relationships between peripheral immune cells and Alzheimer’s disease: a two-sample Mendelian randomization study
ObjectivePrevious research suggests that peripheral immune cells may play a role in the development of Alzheimer's disease (AD). Our study aims to...
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Memory support training and lifestyle modifications to promote healthy aging in persons at risk for Alzheimer's disease: a digital application supported intervention (Brain Boosters)
BackgroundEvidence-based interventions to protect against cognitive decline among older adults at risk for Alzheimer’s disease and related dementias...
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PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimer’s Disease With machine learning: the PREVIEW study protocol
BackgroundAs disease-modifying therapies (DMTs) for Alzheimer's disease (AD) are becoming a reality, there is an urgent need to select cost-effective...
