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Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy
Breast cancer is the most common invasive malignancy in the world, with millions of survivors living today. Type 2 diabetes mellitus (T2DM) is also a...
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Terapia ormonale di affermazione di genere nelle persone transgender e gender diverse
Gender affirming hormonal treatment (GAHT) may be required by some transgender (trans) and gender diverse (GD) people, in order to achieve body...
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Aldosterone-progesterone relationship in sexually intact Chihuahua bitches
BackgroundAldosterone represents an important target of heart failure therapy and may be a valuable indicator of the renin-angiotensin-aldosterone...
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Alterations in the balance of sex hormones may affect rat prostatic inflammation and fibrosis, and osteopontin might be involved in this process
ObjectiveThis study aimed to investigate the effects of sex hormone imbalance on rat prostatic inflammation and fibrosis and identify the key...
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The menopausal transition period and cardiovascular risk
The menopausal transition period spans, on average, 2–8 years before the final menstrual period and is associated with an increase in clinical and...
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Preclinical models of prostate cancer — modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo
Prostate cancer is well known to be dependent on the androgen receptor (AR) for growth and survival. Thus, AR is the main pharmacological target to...
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Resveratrol activates MAPK/ERK pathway to regulate oestrogen metabolism in type I endometrial cancer
ObjectiveEndometrial cancer (EC) is an oestrogen-dependent tumour, the occurrence of which is closely related to an imbalance of oestrogen...
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The Catechol O-Methyltransferase Inhibitor Entacapone in the Treatment of Parkinson’s Disease: Personal Reflections on a First-in-Class Drug Development Programme 40 Years On
In the 1980s, Orion Pharma, then a mid-ranking Nordic area pharmaceutical company, established a drug development programme on the inhibition of...
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Variable effect of the post-partum menstrual cycle on aldosterone and renin in women with recent preeclampsia
The purpose of the present study is to identify the impact of the postpartum menstrual cycle on aldosterone, renin, and their ratio of women with and...
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Effects of natural mating, artificial insemination and intravaginal deposition of raw semen or seminal plasma on vaginal and uterine blood flow in German Holstein cows
AimThe present study was performed to characterize and compare the perfusion of vaginal and uterine arteries after challenging the reproductive tract...
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The interplay between diabetes mellitus and menopause: clinical implications
The menopausal transition is an impactful period in women’s lives, when the risk of cardiovascular disease is accelerated. Similarly, diabetes...
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Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort
BackgroundPlatelet count (PLT) is associated positively with lung cancer risk but has a more complex association with body mass index (BMI), positive...
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Management of mixed urinary incontinence: IUGA committee opinion
Introduction and hypothesisMixed urinary incontinence (MUI) is defined by the International Urogynecology Association (IUGA) and International...
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The tendon unit: biochemical, biomechanical, hormonal influences
The current literature has mainly focused on the biology of tendons and on the characterization of the biological properties of tenocytes and...
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Differences in the epidemiology, management and outcomes of kidney disease in men and women
Improved understanding of differences in kidney disease epidemiology, management and outcomes in men and women could help nephrologists to better...
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Sex-based Differences in Heart Failure Biomarkers
Purpose of ReviewDifferences in HF biomarker levels by sex may be due to hormonal, genetic, and fat distribution differences. Knowledge of these...
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Treating menopause — MHT and beyond
Every woman who lives past midlife will experience menopause, which, by definition, is complete cessation of ovarian function. This process might...
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Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?
We provide an evidence base and guidance for the use of menopausal hormone therapy (MHT) for the maintenance of skeletal health and prevention of...
