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The interplay of galectins-1, -3, and -9 in the immune-inflammatory response underlying cardiovascular and metabolic disease
Galectins are β-galactoside-binding proteins that bind and crosslink molecules via their sugar moieties, forming signaling and adhesion networks...
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Hair Follicle Melanocytes Initiate Autoimmunity in Alopecia Areata: a Trigger Point
Alopecia areata (AA) is characterized by common non-scarring alopecia due to autoimmune disorders. To date, the specific pathogenesis underlying AA...
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Efficacy and safety of immune checkpoint inhibitors plus anlotinib in small cell lung cancer with brain metastases: a retrospective, multicentre study
BackgroundPrevious studies showed that both immune checkpoint inhibitors (ICIs) and anlotinib have central nervous system (CNS) efficacy. This study...
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Peripheral immune cells and perinatal brain injury: a double-edged sword?
AbstractPerinatal brain injury is the leading cause of neurological mortality and morbidity in childhood ranging from motor and cognitive impairment...
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Immunosuppressive Therapy for High-Risk Corneal Transplant
Purpose of ReviewThis review summarizes the efficacy, clinical utility, and adverse event profile of available immunosuppression agents used for...
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Origins and immunopathogenesis of autoimmune central nervous system disorders
The field of autoimmune neurology is rapidly evolving, and recent discoveries have advanced our understanding of disease aetiologies. In this...
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Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound
PurposeGlioblastoma (GB) poses formidable challenges to systemic immunotherapy approaches owing to the paucity of immune infiltration and presence of...
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Treatment of in vitro generated Langerhans cells with JAK-STAT inhibitor reduces their inflammatory potential
Alopecia areata (AA) is a condition in which hair is lost in small regions or over the entire body. It has a prevalence of 1 in 1000 and has a great...
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Platelet-expressed immune checkpoint regulator GITRL in breast cancer
Owing to their key role in several diseases including cancer, activating and inhibitory immune checkpoint molecules are increasingly exploited as...
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Intersecting Inequities in COVID-19 Vaccination: A Discourse Analysis of Information Use and Decision-Making Among Ethnically Diverse Parents in Canada
BackgroundLittle is known about how intersecting social privilege and disadvantage contribute to inequities in COVID-19 information use and vaccine...
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Epigenetics behind tumor immunology: a mini review
Immunogenic- and immune-therapies have become hot spots in the treatment of cancer. Although promising, these strategies are frequently associated...
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Current landscape and challenges ahead of immuno-molecular mechanism and immunotherapy strategy of brain metastases
Brain metastases are the most common central nervous system malignancies in adults. The popular view is that due to the existence of the blood–brain...
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Metabolic reprogramming in the tumor microenvironment of liver cancer
The liver is essential for metabolic homeostasis. The onset of liver cancer is often accompanied by dysregulated liver function, leading to metabolic...
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Immuno-Psychiatry Facts and Prospects
This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential...
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Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis
Session 2 of the 2018 European Association of Hematopathology/Society for Hematopathology Workshop focused on lymphomas arising in immune-privileged...
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Pathogenese der Uveitis
Uveitis, an inflammation of the inner eye, can have various causes: autoimmunity is the most common in Europe, while trauma, infection, or masquerade...
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Intraocular neutralizing antibodies against aflibercept in patients with age related macular degeneration
PurposeTo detect immunoglobulins in aqueous humour of AMD patients after repeated administration of intravitreal aflibercept.
Patients and methods ...
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New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications
In 2024, the World Health Organization (WHO) launched a new classification of lymphoid neoplasms, a revision of the previously used Revised 4th...
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Annular choroidal detachment following intravitreal aflibercept injection in a patient with nivolumab treatment: a case report
BackgroundTo present a novel case that developed annular choroidal detachment after intravitreal anti-vascular endothelial growth factor antibody...
