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Association study of the complement component C4 gene and suicide risk in schizophrenia
Schizophrenia is a severe mental illness and a major risk factor for suicide, with approximately 50% of schizophrenia patients attempting and 10%...
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Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s sarcoma development
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human cancers such as Kaposi’s sarcoma (KS), which represents the...
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The evolutionary cancer gene network theory versus embryogenic hypotheses
The present paper compares the statements of the evolutionary cancer gene-network theory (cancer genome theory) with the statements of embryogenic...
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Emerging therapies to target CNS pathophysiology in multiple sclerosis
The rapidly evolving therapeutic landscape of multiple sclerosis (MS) has contributed to paradigm shifts in our understanding of the biological...
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From clinical to molecular diagnosis: relevance of diagnostic strategy in two cases of branchio-oto-renal syndrome – case report
BackgroundBranchio-oto-renal syndrome (BOR) is an autosomal dominant disorder characterized by deafness, branchiogenic malformations and renal...
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Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus
Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically susceptible individuals, thereby resulting in loss of...
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Antigen presentation in cancer — mechanisms and clinical implications for immunotherapy
Over the past decade, the emergence of effective immunotherapies has revolutionized the clinical management of many types of cancers. However,...
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Mycobacterium paratuberculosis zoonosis is a One Health emergency
A singular pathogen has been killing animals, contaminating food and causing an array of human diseases. Mycobacterium avium subspecies paratuberculosis...
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Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension
Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically...
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Transactivation of human endogenous retroviruses by tumor viruses and their functions in virus-associated malignancies
Human endogenous retroviruses (HERVs), viral-associated sequences, are normal components of the human genome and account for 8–9% of our genome....
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An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development
The BTBR T + Itpr3 tf /J (BTBR/J) strain is one of the most valid models of idiopathic autism, serving as a potent forward genetics tool to dissect the...
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Inflammation in multiple sclerosis: consequences for remyelination and disease progression
Despite the large number of immunomodulatory or immunosuppressive treatments available to treat relapsing–remitting multiple sclerosis (MS),...
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Transdiagnostic inflammatory subgroups among psychiatric disorders and their relevance to role functioning: a nested case-control study of the ALSPAC cohort
Individuals with psychotic disorders and depressive disorder exhibit altered concentrations of peripheral inflammatory markers. It has been suggested...
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A cross-sectional study of ERG expression and the relationship with clinicopathological features of Prostate cancer in Southwestern Uganda
BackgroundProstate cancer is the leading cause of cancer-related death and the second most commonly diagnosed cancer among men in Uganda and most...
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Pharmacotherapy for Amyotrophic Lateral Sclerosis: A Review of Approved and Upcoming Agents
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder involving loss of upper and lower motor neurons, with most...
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Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat hypermethylated silencing of endogenous retroviral sequences
BackgroundHerbal remedies of Echinacea purpurea tinctures are widely used today to reduce common cold respiratory tract infections.
Methods ...
