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Co-inheritance of recombined chromatids maintains heterozygosity in a parthenogenetic ant
According to Mendel’s second law, chromosomes segregate randomly in meiosis. Non-random segregation is primarily known for cases of selfish meiotic...
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Genomic heterozygosity is associated with a lower risk of osteoarthritis
BackgroundGenomic heterozygosity has been shown to confer a health advantage in humans and play a protective role in complex diseases. Given...
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Extensive sequence duplication in Arabidopsis revealed by pseudo-heterozygosity
BackgroundIt is apparent that genomes harbor much structural variation that is largely undetected for technical reasons. Such variation can cause...
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Loss of Heterozygosity and Its Importance in Evolution
Loss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous loci to homozygous loci. This mutation event is widespread...
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DNA analyses reveal high heterozygosity values and low differentiation among populations of mezcal-producing Agave durangensis
Mezcal is a distilled alcoholic beverage made from different species of agaves. In the state of Durango (Mexico) mezcal production depends on Agave...
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SNP heterozygosity, relatedness and inbreeding of whole genomes from the isolated population of the Faroe Islands
BackgroundThe population of the Faroe Islands is an isolated population but very little is known about it from whole genome sequencing. The...
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Recurrent neural network for predicting absence of heterozygosity from low pass WGS with ultra-low depth
BackgroundThe absence of heterozygosity (AOH) is a kind of genomic change characterized by a long contiguous region of homozygous alleles in a...
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Heterozygosity analysis of spontaneous 2n female gametes and centromere mapping of the diploid Hevea brasiliensis based on full-sib triploid populations
Key messageUnreduced megagametophytes via second-division restitution were confirmed through heterozygosity analysis, and four candidate physical...
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Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens
BackgroundHybrids are chimeric organisms with highly plastic heterozygous genomes that may confer unique traits enabling the adaptation to new...
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High genome heterozygosity revealed vegetative propagation over the sea in Moso bamboo
BackgroundMoso bamboo ( Phyllostachys edulis ) is a typical East Asian bamboo that does not flower for > 60 years and propagates without seed...
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Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts
The p53 tumor suppressor, encoded by the TP53 gene, serves as a major barrier against malignant transformation. Patients with Li-Fraumeni syndrome...
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Genomic heterozygosity is associated with parasite abundance, but the effects are not mediated by host condition
Whether, when, and how genetic diversity buffers individuals and populations against infectious disease risk is a critical and open question for...
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A high heterozygosity genome assembly of Aedes albopictus enables the discovery of the association of PGANT3 with blood-feeding behavior
The Asian tiger mosquito, Aedes albopictus , is a global invasive species, notorious for its role in transmitting dangerous human arboviruses such as...
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Resequencing of 388 cassava accessions identifies valuable loci and selection for variation in heterozygosity
BackgroundHeterozygous genomes are widespread in outcrossing and clonally propagated crops. However, the variation in heterozygosity underlying key...
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Insignificant effects of loss of heterozygosity in HLA in the efficacy of immune checkpoint blockade treatment
BackgroundIt is assumed that loss of heterozygosity and allelic copy loss in HLA gene is associated with poor response rates in immune checkpoint...
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Ionizing radiation induces cells with past caspase activity that contribute to the adult organ in Drosophila and show reduced Loss of Heterozygosity
There is increasing recognition that cells may activate apoptotic caspases but not die, instead displaying various physiologically relevant...
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Assessing SNP Heterozygosity in Potato (Solanum) Species— Bias Due to Missing and Non-allelic Genotypes
Potato has about 100 related wild Solanum species growing naturally in the Americas. The US Potato Genebank aims to keep samples useful for research...
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Migration of repetitive DNAs during evolution of the permanent translocation heterozygosity in the oyster plant (Tradescantia section Rhoeo)
Due to translocation heterozygosity for all chromosomes in the cell complement, the oyster plant ( Tradescantia spathacea ) forms a complete meiotic...
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Functional studies associate novel DUOX2 gene variants detected in heterozygosity to Crohn’s disease
PurposeCrohn’s disease is a chronic gastrointestinal inflammatory disease with possible extraintestinal symptoms. There are predisposing genetic...
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Characterization of runs of homozygosity, heterozygosity-enriched regions, and population structure in cattle populations selected for different breeding goals
BackgroundA decline in the level of genetic diversity in livestock can result in reduced response to selection, greater incidence of genetic defects,...
