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Transcription Factor Regulatory Networks
This book covers various state-of-the-art techniques regarding the associations between transcription factors (TFs) and genes, with a focus on...
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Transcription Factor TAL1 in Erythropoiesis
Lineage-specific transcription factors (TFs) regulate differentiation of hematopoietic stem cells (HSCs). They are decisive for the establishment and...
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Nuclear Transcription Factor Detection
Cellular fate is determined by the activity of nuclear transcription factors. Here, we describe a series of protocols for detecting transcription...
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Database for Plant Transcription Factor Binding Sites
Reconstruction of gene regulatory networks is a very important but difficult issue in plant sciences. Recently, numerous high-throughput techniques,...
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Transcription Factor NRF2 in Endothelial Functions
AbstractThe transcription factor NRF2 is a major regulator of cell antioxidant defense. NRF2 is activated by various stimuli, such as oxidants and...
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Exploring Plant Transcription Factor Databases and Regulatory Networks
This chapter provides an analysis of the involvement of transcription factors (TFs) in plant genomes. To enhance the knowledge of the regulatory...
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Assessing the Activity of Transcription Factor FoxO1
The transcription factor FoxO1 (forkhead box O1) regulates genes that are involved in development, metabolism, cellular innovation, longevity, and...
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Early B-Cell Factor 1: An Archetype for a Lineage-Restricted Transcription Factor Linking Development to Disease
The development of highly specialized blood cells from hematopoietic stem cells (HSCs) in the bone marrow (BM) is dependent upon a stringently...
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The Method of Screening and Identification of Transcription Factor in Klebsiella
This protocol describes a method for verifying the specific transcription factor regulating glycerol dehydratase (GDH) expression in Klebsiella. DNA...
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Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function
NFE2-related factor 2 (NRF2) is a master transcription factor (TF) that coordinates key cellular homeostatic processes including antioxidative...
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Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet
BackgroundTranscription factors bind DNA in specific sequence contexts. In addition to distinguishing one nucleobase from another, some transcription...
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The regulatory relationship between transcription factor STAT3 and noncoding RNA
Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor...
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Transcription factor Sp1 transcriptionally enhances GSDME expression for pyroptosis
Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3, plays a crucial role in tumor defense and the response to chemotherapy...
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Key Functions of the Transcription Factor BCL6 During T-Cell Differentiation
T lymphocytes consist of several subtypes with distinct functions that help to coordinate an immune response. They are generated within the thymus...
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Flexible modeling of regulatory networks improves transcription factor activity estimation
Transcriptional regulation plays a crucial role in determining cell fate and disease, yet inferring the key regulators from gene expression data...
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Transcription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma
Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients’ survival and became the first-line...
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Identification of transcription factor high accumulation DNA zones
BackgroundTranscription factors (TF) play a crucial role in the regulation of gene transcription; alterations of their activity and binding to DNA...
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Transcription factors in blood cell development
This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific...
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Construction of Gene Expression Profiles of the NAC Transcription Factor Family in Sugar Beet Under Abiotic Stress
Sugar beet ( Beta vulgaris L.) is a major sugar crop in China and an economic crop with regional advantages in the Inner Mongolia Autonomous Region....
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Nuclear Tubulin Enhances CXCR4 Transcription and Promotes Chemotaxis Through TCF12 Transcription Factor in human Hematopoietic Stem Cells
Tubulins are cytoskeleton components in all eukaryotic cells and play crucial roles in various cellular activities by polymerizing into dynamic...
