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Squalene hopene cyclases and oxido squalene cyclases: potential targets for regulating cyclisation reactions
Squalene hopene cyclases (SHC) convert squalene, the linear triterpene to fused ring product hopanoid by the cationic cyclization mechanism. The main...
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Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains...
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Squalene production under oxygen limitation by Schizochytrium sp. S31 in different cultivation systems
AbstractThe triterpene squalene is widely used in the food, cosmetics and pharmaceutical industries due to its antioxidant, antistatic and...
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Bioprocess conditions and regulation factors to optimize squalene production in thraustochytrids
Squalene is a widely distributed natural triterpene, as it is a key precursor in the biosynthesis of all sterols. It is a compound of high commercial...
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Molecular docking and simulation studies of squalene obtained from Amaranthus Hybridus with DNA topoisomerase II alpha
DNA-Topoisomerases (DNA-Topo) are universal nuclear enzymes which deal with the DNA topology during cellular activities. These are the important and...
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Molecular Cloning of a cDNA for Chrysanthemum morifolium Ramat Squalene Synthase Gene and Impact of Its Silencing on Transgenic Chrysanthemum Plants
AbstractThe aim of this research was to study the impact of squalene synthase gene silencing on the features of transgenic chrysanthemum plants, and...
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Recent advances in the microbial production of squalene
Squalene is a triterpene hydrocarbon, a biochemical precursor for all steroids in plants and animals. It is a principal component of human surface...
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Genetic regulation and fermentation strategy for squalene production in Schizochytrium sp.
AbstractSqualene, as an important terpenoid, is extensively used in the medicine and health care fields owing to its functions of anti-oxidation,...
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Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB
BackgroundWhile de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular...
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Enhancement of Squalene Production by Constitutive Expression of the 3-Hydroxy-3-Methylglutaryl-CoA Reductase in Aurantiochytrium sp. 18W-13a
Squalene has a wide range of applications in the industry sectors of dietary supplements, cosmetics, immunization, and pharmaceuticals. Yet, suitable...
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Identification and functional characterization of two trans-isopentenyl diphosphate synthases and one squalene synthase involved in triterpenoid biosynthesis in Platycodon grandiflorus
Main conclusionTwo trans -isopentenyl diphosphate synthase and one squalene synthase genes were identified and proved to be involved in the...
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Enhanced Immune Responses Against Mycobacterium tuberculosis Through Heat-Killed BCG with Squalene-in-water Emulsion Adjuvant
The increasing challenge of drug-resistant tuberculosis (TB) calls for the development of innovative therapeutic strategies, highlighting the...
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Molecular cloning and functional characterization of two squalene synthase genes in Atractylodes lancea
Main conclusionTwo squalene synthase genes AlSQS1 and AlSQS2 were isolated from
Atractylodes lancea and functionally characterized using in vitro...
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Squalene deters drivers of RCC disease progression beyond VHL status
Identifying drug candidates to target cellular events/signaling that evades von Hippel-Lindau tumor suppressor ( VHL ) gene interaction is critical for...
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Bioprospecting potentials of moderately halophilic bacteria and the isolation of squalene producers from Kuwait sabkha
Sabkhas in Kuwait are unique hypersaline marine environments under-explored for bacterial community composition and bioprospecting. The 16S rRNA...
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Heterologous expression of Chlorophytum borivilianum Squalene epoxidase in tobacco modulates stigmasterol production and alters vegetative and reproductive growth
KeymessageCbSE overexpression increased stigmasterol levels and altered plant morphology. The genes upstream and downstream of CbSE were found to be... 
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Overexpression of the squalene epoxidase gene (PgSE1) resulted in enhanced production of ginsenosides and phytosterols in transgenic ginseng
Squalene epoxidase (also called squalene monooxygenase) catalyses the conversion of squalene into 2,3-oxidosqualene by epoxidation and is regarded as...
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4–4′ Diaponeurosporenic Acid, the C30 Carotenoid Pigment in Endophytic Pseudomonas Mendocina with Squalene Cyclase Activity
Even though organisms with squalene hopene cyclase activity involved in hopanoid synthesis has been reported earlier, their existence along with...
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Metabolic engineering of Saccharomyces cerevisiae for high-level production of (+)-ambrein from glucose
(+)-Ambrein is the primary component of ambergris, a rare product found in sperm whales ( Physeter microcephalus ). Microbial production using...
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Transcriptome-wide identification of squalene epoxidase genes from Glycyrrhiza glabra L.: expression analysis and heterologous expression of GgSQE1 suggest important role in terpenoid biosynthesis
Squalene epoxidase (SQE) is a crucial regulatory enzyme for the biosynthesis of several important classes of compounds including sterols and...
