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Induction of liver transplant immune tolerance in an outbred rat strain model using tacrolimus
BackgroundOrthotopic liver transplantation is the only option for patients with end-stage liver disease and hepatocellular carcinoma. Post-transplant...
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Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures
BackgroundSocial behavior and social organization have major influences on individual health and fitness. Yet, biomedical research focuses on...
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Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
AbstractMitochondrial uncoupling protein (UCP1) facilitates adaptive non-shivering thermogenesis in brown and beige adipocytes due to uncoupling of...
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Characterizing phenotypic data of Peromyscus leucopus compared to C57BL/6J Mus musculus and diversity outbred (DO) Mus musculus
Translational research is commonly performed in the C57B6/J mouse strain, chosen for its genetic homogeneity and phenotypic uniformity. Here, we...
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Mouse Cloning Using Outbred Oocyte Donors and Nontoxic Reagents
Somatic cell nuclear transfer (SCNT) technology has become a useful tool for animal cloning, gene manipulation, and genomic reprogramming research....
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Longitudinal fragility phenotyping contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice
Aging studies in mammalian models often depend on natural lifespan data as a primary outcome. Tools for lifespan prediction could accelerate these...
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Phenotyping spontaneous locomotor activity in inbred and outbred mouse strains by using Digital Ventilated Cages
Mouse strains differ markedly in all behaviors, independently of their genetic background. We undertook this study to disentangle the diurnal...
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An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice
Type 2 diabetes (T2D) is a complex metabolic disorder with no cure and high morbidity. Exposure to inorganic arsenic (iAs), a ubiquitous...
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Resilience, plasticity and robustness in gene expression during aging in the brain of outbred deer mice
BackgroundGenes that belong to the same network are frequently co-expressed, but collectively, how the coordination of the whole transcriptome is...
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Inbreeding affects juvenile shoaling behaviour in sibling groups of a cichlid fish
Whilst the effects of inbreeding on growth and survival have been well studied, knowledge on the impact of inbreeding on the social behaviour is...
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Sex-specific effects of inbreeding on body colouration and physiological colour change in the cichlid fish Pelvicachromis taeniatus
BackgroundColour expression is highly variable in animals. In fishes, rapid colour change, i.e. physiological colour change, can be observed in...
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Productivity of Young Rabbits of a Newly Created Breed
AbstractThe goal of the study was to identify the best mating strategy for the creation of a new rabbit breed according to the results of the...
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Taste association capabilities differ in high- and low-yawning rats versus outbred Sprague–Dawley rats after prolonged sugar consumption
Yawning is a stereotypical behavior pattern commonly associated with other behaviors such as grooming, sleepiness, and arousal. Several differences...
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Effects of inbreeding on fertilization, growth and survival in the tetraploid Pacific oyster Crassostrea gigas
Induced homologous tetraploid oysters are typically derived from a limited number of effective parents, with subsequent breeding steps likely to...
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Salinity tolerance and early survival of F1 hatchlings crossbred between amphidromous and landlocked strains of ayu under experimental condition
The ayu, Plecoglossus altivelis , with an amphidromous life migrating between the sea and streams, is a commercially important fish for the inland...
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Immunocompetent Mice As a Model for Preclinical Studies of mRNA Vaccine Immunogenicity
AbstractConducting preclinical studies of mRNA vaccines is complicated by the lack of relevant animal models of the human immune system....
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Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been implicated in inflammatory processes....
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A model for evolutionary rescue through plant mating system
As reported by experimental studies, changes in pollination regime are expected to drive plant mating system evolution. In natural populations facing...
