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Treatment of Syringomyelia Characterized by Focal Dilatation of the Central Canal Using Mesenchymal Stem Cells and Neural Stem Cells
BACKGROUND:Syringomyelia is a progressive chronic disease that leads to nerve pain, sensory dissociation, and dyskinesia. Symptoms often do not...
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Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury
AbstractActivation of endogenous neural stem cells (NSC) is one of the most potential measures for neural repair after spinal cord injury. However,...
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Neural Stem Cells
The introduction of neural stem cells (NSCs) from adult mouse brains by Brent Reynold and Samuel Swiss in 1992 not only paved the way for in vitro...
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Neural Stem Cells
The introduction of neural stem cells (NSCs) from adult mouse brains by Brent Reynold and Samuel Swiss in 1992 not only paved the way for in vitro...
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Single-cell Profiling of Reprogrammed Human Neural Stem Cells Unveils High Similarity to Neural Progenitors in the Developing Central Nervous System
BackgroundSimilar to induced pluripotent cells (iPSCs), induced neural stem cells (iNSCs) can be directly converted from human somatic cells such as...
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Dying transplanted neural stem cells mediate survival bystander effects in the injured brain
Neural stem and progenitor cell (NSPC) transplants provide neuroprotection in models of acute brain injury, but the underlying mechanisms are not...
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Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells
Stem cell-based therapy is a potential alternative strategy for brain repair, with neural stem cells (NSC) presenting as the most promising...
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Glioma stem cells and neural stem cells respond differently to BMP4 signaling
Malignant glioma is a highly heterogeneous and invasive primary brain tumor characterized by high recurrence rates, resistance to combined therapy,...
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Directional induction of neural stem cells, a new therapy for neurodegenerative diseases and ischemic stroke
Due to the limited capacity of the adult mammalian brain to self-repair and regenerate, neurological diseases, especially neurodegenerative disorders...
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Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo
BackgroundStem cell therapy is a promising therapeutic strategy. In a previous study, we evaluated tumorigenicity by the stereotactic transplantation...
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Transplantation of Neural Progenitor Cells Derived from Stem Cells from Apical Papilla Through Small-Molecule Induction in a Rat Model of Sciatic Nerve Injury
Background:Stem cell-based transplantation therapy holds promise for peripheral nerve injury treatment, but adult availability is limited. A cell...
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Transcriptional and epigenetic dysregulation impairs generation of proliferative neural stem and progenitor cells during brain aging
The decline in stem cell function during aging may affect the regenerative capacity of mammalian organisms; however, the gene regulatory mechanism...
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Nutrition, Epigenetics, and Stem Cells
Stem cells represent the regenerative capacity of our bodies; hence, it is essential for these cells to interact with the intrinsic and extrinsic...
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Differentiation of Neurons, Astrocytes, Oligodendrocytes and Microglia From Human Induced Pluripotent Stem Cells to Form Neural Tissue-On-Chip: A Neuroinflammation Model to Evaluate the Therapeutic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells
Advances in stem cell (SC) technology allow the generation of cellular models that recapitulate the histological, molecular and physiological...
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EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory
Many brain diseases lead to a reduction in the number of functional neurons and it would be of value to be able to increase the number of neurons in...
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The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive...
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Oxidized SOD1 accelerates cellular senescence in neural stem cells
BackgroundNeural stem cells (NSCs), especially human NSCs, undergo cellular senescence characterized by an irreversible proliferation arrest and loss...
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GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke
BackgroundBrainstem stroke causes severe and persistent neurological impairment. Due to the limited spontaneous recovery and regeneration of the...
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MicroRNA Profiling of Self-Renewing Human Neural Stem Cells Reveals Novel Sets of Differentially Expressed microRNAs During Neural Differentiation In Vitro
The involvement of microRNAs (miRNAs) in orchestrating self-renewal and differentiation of stem cells has been revealed in a number of recent...
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Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions
BackgroundGlioblastoma is one of the most common and aggressive adult brain tumors. The conventional treatment strategy, surgery combined with...
