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USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that drives the synthesis of dolichol, heme A, ubiquinone and...
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Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy
With aging, abnormalities during oocyte meiosis become more prevalent. However, the mechanisms of aging-related oocyte aneuploidy are not fully...
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The non-mevalonate pathway requires a delicate balance of intermediates to maximize terpene production
AbstractTerpenes are valuable industrial chemicals whose demands are increasingly being met by bioengineering microbes such as E. coli . Although the...
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Synthesis of pinene in the industrial strain Candida glycerinogenes by modification of its mevalonate pathway
Terpenes have many applications and are widely found in nature, but recent progress in synthetic biology has enabled the use of microorganisms as...
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Production of mevalonate in Pseudomonas putida via tuning the expression of pathway gene
Beyond its potential for biofuel production, Pseudomonas putida ’s capability to metabolize lignin and other lignocellulosic materials earmarks it as...
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p140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells
p140Cap is an adaptor protein involved in assembling multi-protein complexes regulating several cellular processes. p140Cap acts as a tumor...
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The Effect of Mevalonate, Zoledronate, and BCG Induction on the Monocyte/Macrophage Phenotype
AbstractInnate immune cells, mainly monocytes/macrophages, upon their first encounter with a pathogen, form long-term nonspecific immunological...
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MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC....
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m6A-dependent mevalonate kinase in juvenile hormone synthesis pathway regulates the diapause process of bivoltine silkworm (Bombyx mori)
BackgroundResearch has shown that epigenetic modification are involved the regulation of diapause in bivoltine silkworms ( Bombyx mori ), but it...
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Deubiquitinase USP35 stabilizes BRPF1 to activate mevalonate (MVA) metabolism during prostate tumorigenesis
The mutual interplay between epigenetic modifications and metabolic rewiring contributes to malignant features of prostate adenocarcinoma (PRAD)....
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Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer
Small cell lung cancer (SCLC) lacks effective treatments to overcome chemoresistance. Here we established multiple human chemoresistant xenograft...
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Molecular cloning and characterization of Triterpenoid Biosynthetic Pathway Gene HMGS in Centella asiatica (Linn.)
BackgroundThe flux of isoprenoids and the total accumulation of triterpenoid saponins known as centellosides in C. asiatica are controlled by the...
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ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma
Cancer is, fundamentally, a disorder of cell growth and proliferation, which requires adequate supplies of energy and nutrients. In this study, we...
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Improve the production of d-limonene by regulating the mevalonate pathway of Saccharomyces cerevisiae during alcoholic beverage fermentation
d- Limonene, a cyclized monoterpene, possesses citrus-like olfactory property and multi-physiological functions, which can be used as a bioactive...
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RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway
BackgroundOsteosarcoma (OS) is the most prevalent primary bone malignancy affecting adolescents, yet the emergence of chemoradiotherapeutic...
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Full-length transcriptome profiling of Acanthopanax gracilistylus provides new insight into the kaurenoic acid biosynthesis pathway
Acanthopanax gracilistylus is a deciduous plant in the family Araliaceae, which is commonly used in Chinese herbal medicine, as the root bark has...
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Manipulation of DXP pathway for andrographolide production in callus cultures of Andrographis paniculata
Main conclusionGreening of in vitro callus cultures and andrographolide over-accumulation was achieved by manipulating light exposure and media...
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Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a complex gynaecological endocrine disease that occurs in women of childbearing age. The pathogenesis of PCOS is...
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Insights into Regulating Mechanism of Mutagenesis Strains of Elizabethkingia meningoseptica sp. F2 by Omics Analysis
Vitamin K 2 plays an important role in electron transport, blood coagulation, and calcium homeostasis, and researchers have been trying to use...
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Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression
The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus regulating tissue homeostasis. The pathway acts through...
