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Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements
RAF kinases are integral to the RAS-MAPK signaling pathway, and proper RAF1 folding relies on its interaction with the chaperone HSP90 and the...
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Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells
HSP90 has emerged as an appealing anti-cancer target. However, HSP90 inhibitors (HSP90i) are characterized by limited clinical utility, primarily due...
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Detecting Posttranslational Modifications of Hsp90 Isoforms
The molecular chaperone heat shock protein 90 (Hsp90) is essential in eukaryotes. Hsp90 chaperones proteins that are important determinants of...
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Functions of the Hsp90-Binding FKBP Immunophilins
The Hsp90 chaperone is known to interact with a diverse array of client proteins. However, in every case examined, Hsp90 is also accompanied by a...
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Structural basis for the dynamic chaperoning of disordered clients by Hsp90
Molecular chaperone heat shock protein 90 (Hsp90) is a ubiquitous regulator that fine-tunes and remodels diverse client proteins, exerting profound...
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Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation...
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HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein-folding, quality...
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Structural and functional complexity of HSP90 in cellular homeostasis and disease
Heat shock protein 90 (HSP90) is a chaperone with vital roles in regulating proteostasis, long recognized for its function in protein folding and...
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Impact of Co-chaperones and Posttranslational Modifications Toward Hsp90 Drug Sensitivity
Posttranslational modifications (PTMs) regulate myriad cellular processes by modulating protein function and protein-protein interaction. Heat shock...
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Chromatin Immunoprecipitation (ChIP) of Heat Shock Protein 90 (Hsp90)
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a widely used technique for genome-wide...
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The chaperone system in cancer therapies: Hsp90
The chaperone system (CS) of an organism is composed of molecular chaperones, chaperone co-factors, co-chaperones, and chaperone receptors and...
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Salidroside promotes healthy longevity by interfering with HSP90 activity
Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medications to combat aging and delay...
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Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells
Colon cancer is a major cause of cancer-related death. Despite recent improvements in the treatment of colon cancer, new strategies to improve the...
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Cdc37 as a Co-chaperone to Hsp90
The co-chaperone p50/Cdc37 is an important partner for Hsp90, assisting in molecular chaperone activities, particularly with regard to the regulation...
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Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid...
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Hsp70/Hsp90 Organising Protein (Hop): Coordinating Much More than Chaperones
The Hsp70/Hsp90 organising protein (Hop, also known as stress-inducible protein 1/STI1/STIP1) has received considerable attention for diverse...
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HSP90, as a functional target antigen of a mAb 11C9, promotes stemness and tumor progression in hepatocellular carcinoma
BackgroundIdentification of promising targeted antigens that exhibited cancer-specific expression is a crucial step in the development of novel...
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HSP90 mediates the connection of multiple programmed cell death in diseases
Heat shock protein (HSP) 90, an important component of the molecular chaperone network, is closely concerned with cellular signaling pathways and...
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Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis
BackgroundThe activated microglia have been reported as pillar factors in neuropathic pain (NP) pathology, but the molecules driving pain-inducible...
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circSLC4A7 accelerates stemness and progression of gastric cancer by interacting with HSP90 to activate NOTCH1 signaling pathway
Gastric cancer stem cells (GCSCs) play critical roles in gastric cancer (GC) initiation and development. Circular RNAs (circRNAs) participate in...
