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Specification of Hsp70 Function by Hsp40 Co-chaperones
Cellular homeostasis and stress survival requires maintenance of the proteome and suppression of proteotoxicity. Molecular chaperones promote cell...
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HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is one of the deadliest forms of cancer with limited therapy...
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Ectopic BH3-Only Protein Bim Associates with Hsp70 to Regulate Yeast Mitophagy
AbstractMitophagy, a form of selective autophagy, plays an essential role to maintain a population of healthy and functional mitochondria for normal...
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HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein-folding, quality...
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HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma
BackgroundNecroptosis, a newly defined regulatable necrosis with membrane disruption, has been demonstrated to participate in trauma brain injury...
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Hsp70 Knockdown in the Brine Shrimp Artemia franciscana: Implication on Reproduction, Immune Response and Embryonic Cuticular Structure
The potential functional role(s) of heat shock protein 70 (Hsp70) in the brine shrimp, Artemia franciscana , a crucial crustacean species for...
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HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway
HSP70 exhibits neuroprotective, antioxidant, and anti-apoptotic properties, which are crucial in preventing spinal cord injury (SCI) induced by...
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Hsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex
BackgroundFor cancer therapy, the identification of both selective autophagy targets and small molecules that specifically regulate autophagy is...
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The Protective Action of Hsp70 and Hydrogen Sulfide Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory Response by Modulating Endocytosis
Abstract —Hsp70 and hydrogen sulfide donors reduce inflammatory processes in human and animal cells. The biological action mediated by Hsp70 and H 2 S...
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Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation
BackgroundPD-1 blockade has shown impressive clinical outcomes in colorectal cancers patients with high microsatellite instability (MSI-H). However,...
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HSP70-binding motifs function as protein quality control degrons
Protein quality control (PQC) degrons are short protein segments that target misfolded proteins for proteasomal degradation, and thus protect cells...
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Ultrashort wave diathermy inhibits pulmonary inflammation in mice with acute lung injury in a HSP70 independent way: a pilot study
BackgroundAcute lung injury (ALI) is a clinical syndrome characterized by pulmonary inflammation. Ultrashort wave diathermy (USWD) has been shown to...
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Osmoregulation and HSP70 abundance in freshwater catfish Rhamdia quelen under acute salt exposure
Understanding how freshwater species respond to changes in salinity is essential for comprehending their distribution and ecological niches. We...
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Hsp70/Hsp90 Organising Protein (Hop): Coordinating Much More than Chaperones
The Hsp70/Hsp90 organising protein (Hop, also known as stress-inducible protein 1/STI1/STIP1) has received considerable attention for diverse...
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Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells involves p53 and Hsp70
Although it has been established that cannabidiol (CBD), the major non-psychoactive constituent of cannabis, exerts antitumoral activities, the exact...
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Assessment of Heat-Shock Protein Hsp70 Colocalization with Markers of Tumor Stem-Like Cells
AbstractThe search of biomarkers for early diagnosis and theranostics of glioblastoma multiforme (GBM) due to the aggressiveness of the disease is an...
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Immunohistochemical, Flow Cytometric, and ELISA-Based Analyses of Intracellular, Membrane-Expressed, and Extracellular Hsp70 as Cancer Biomarkers
The major stress-inducible 70 kDa heat shock (stress) protein 70 (Hsp70) is frequently overexpressed in highly aggressive tumor cells and thus might...
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Capsaicin combined with stem cells improved mitochondrial dysfunction in PIG3V cells, an immortalized human vitiligo melanocyte cell line, by inhibiting the HSP70/TLR4/mTOR/FAK signaling axis
BackgroundVitiligo is a common autoimmune skin disease. Capsaicin has been found to exert a positive effect on vitiligo treatment, and mesenchymal...
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Transfection of Heat Shock Protein 70 kDa (HSP70)
Heat shock protein 70 kDa (HSP70) is a major protein family in the cell protections against stress-induced denaturation and aggregation and in the...
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Nucleotide Exchange Factors for Hsp70 Molecular Chaperones: GrpE, Hsp110/Grp170, HspBP1/Sil1, and BAG Domain Proteins
Molecular chaperones of the Hsp70 family are key components of the cellular protein-folding machinery. Substrate folding is accomplished by iterative...
