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Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning
Cancer is one of the leading causes of death worldwide and can be caused by environmental aspects (for example, exposure to asbestos), by human...
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An immunogenic cell death-related gene expression signature in predicting prognosis of pancreatic ductal adenocarcinoma
BackgroundImmunogenic cell death (ICD) has been identified as regulated cell death, which is sufficient to activate the adaptive immune response....
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Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice
During the lifetime of females, mammary epithelial cells undergo cyclical expansion and proliferation depending on the cyclical activation of mammary...
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Construction of immune-related gene pairs signature to predict the overall survival of multiple myeloma patients based on whole bone marrow gene expression profiling
Multiple myeloma (MM) is a plasma cell dyscrasia that is characterized by the uncontrolled proliferation of malignant PCs in the bone marrow. Due to...
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A mesocorticolimbic signature of pleasure in the human brain
Pleasure is a fundamental driver of human behaviour, yet its neural basis remains largely unknown. Rodent studies highlight opioidergic neural...
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Featured lncRNA-based signature for discriminating prognosis and progression of hepatocellular carcinoma
Long non-coding RNAs (lncRNAs) have been implicated in carcinogenesis and progression of hepatocellular carcinoma (HCC). This study aimed to identify...
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Prognostic significance of a signature based on senescence-related genes in colorectal cancer
Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease...
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Machine learning to establish three sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with gastric cancer
BackgroundGastric cancer (GC) is one of the most common malignant tumors worldwide. Nevertheless, GC still lacks effective diagnosed and monitoring...
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1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature
Uveal melanoma (UM) is an ocular cancer, with propensity for lethal liver metastases. When metastatic UM (MUM) occurs, as few as 8% of patients...
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Whole blood transcriptome signature predicts severe forms of COVID-19: Results from the COVIDeF cohort study
COVID-19 is associated with heterogeneous outcome. Early identification of a severe progression of the disease is essential to properly manage the...
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A robust immune-related gene pairs signature for predicting the overall survival of esophageal cancer
BackgroundIdentifying reliable biomarkers could effectively predict esophagus carcinoma (EC) patients with poor prognosis. In this work, we...
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A common gene signature of the right ventricle in failing rat and human hearts
The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic...
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A lipid metabolism-related gene signature reveals dynamic immune infiltration of the colorectal adenoma-carcinoma sequence
BackgroundLipid metabolism-related genes (LMRGs) have been reported to be correlated with the immune infiltration of colorectal cancer (CRC). This...
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Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma
BackgroundCuproptosis is a new type of copper-induced cell death that is characterized by the aggregation of lipoylated tricarboxylic acid (TCA)...
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A novel prognostic signature for clear cell renal cell carcinoma constructed using necroptosis-related miRNAs
BackgroundThis work aims to analyze the relationship between necroptosis-related microRNAs (miRNAs) and the prognosis of clear cell renal cell...
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Molecular Characterization of Cuproptosis-related lncRNAs: Defining Molecular Subtypes and a Prognostic Signature of Ovarian Cancer
Cuproptosis, a newly discovered form of programmed cell death, relies on mitochondrial respiration, the chain of which has been found to be altered...
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Identification of a DNA damage repair-related LncRNA signature for predicting the prognosis and immunotherapy response of hepatocellular carcinoma
BackgroundDNA damage repair (DDR) may affect tumorigenesis and therapeutic response in hepatocellular carcinoma (HCC). Long noncoding RNAs (LncRNAs)...
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Cuproptosis-related lncRNA signature for prognostic prediction in patients with acute myeloid leukemia
BackgroundLong non-coding RNAs (lncRNAs) have been reported to have a crucial impact on the pathogenesis of acute myeloid leukemia (AML)....
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Deciphering climate resilience in Indian cattle breeds by selection signature analyses
The signature of selection is a crucial concept in evolutionary biology that refers to the pattern of genetic variation which arises in a population...
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Development and validation of a two glycolysis-related LncRNAs prognostic signature for glioma and in vitro analyses
BackgroundMounting evidence suggests that there is a complex regulatory relationship between long non-coding RNAs (lncRNAs) and the glycolytic...
