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Apoptosis Detection Assays
Many apoptosis assays are available since there are many proteins regulated at multiple points and involved in apoptosis signaling cascade. To detect...
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Systems biology of apoptosis
New approaches are required for the mathematical modelling and system identification of complex signal transduction networks, which are characterized...
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Cell Death by Apoptosis
Apoptosis is a phenomenon involving multiple sequential molecular steps that lead to cell death. The intrinsic pathway and extrinsic pathway are two...
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Yeast as a model for ageing and apoptosis research
Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an...
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Multiparametric Analysis of Apoptosis by Flow Cytometry
Flow cytometry remains the most widely used method for detecting and quantifying apoptosis and related forms of cell death in mammalian cells. The...
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Potentiation of apoptosis in drug-resistant mantle cell lymphoma cells by MCL-1 inhibitor involves downregulation of inhibitor of apoptosis proteins
Bruton’s tyrosine kinase inhibitors (BTKi) and CAR T-cell therapy have demonstrated tremendous clinical benefits in mantle cell lymphoma (MCL)...
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Biochemistry of Apoptosis and Autophagy
One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated....
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Senescence and Apoptosis: ROS Contribution to Stress Tolerance or Cellular Impairment
Senescence and apoptosis are crucial developmental processes that take place during plant growth and development. Senescence is a genetically...
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SAM68 directs STING signaling to apoptosis in macrophages
DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to...
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The dual role of mesenchymal stem cells in apoptosis regulation
Mesenchymal stem cells (MSCs) are widely distributed pluripotent stem cells with powerful immunomodulatory capacity. MSCs transplantation therapy...
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Analysis of Proliferation, Apoptosis, and Motility in Mouse Embryonic Melanocytic Precursor Cells
In this chapter, we provide a method to purify and culture embryonic melanocytic stem cells that express green fluorescent protein in a cell-type...
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miRNAs that regulate apoptosis in breast cancer and cervical cancer
In today’s world, one of the main problems is cancer, which still has a long way to go to cure it, and it brings a lot of financial and emotional...
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Genetic influence on vascular smooth muscle cell apoptosis
Vascular smooth muscle cell (VSMC) proliferation, migration, and apoptosis play important roles in many physiological processes and pathological...
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HMGA1 regulates the mitochondrial apoptosis pathway in sepsis-induced cardiomyopathy
High mobility group protein AT-hook 1 (HMGA1), an architectural transcription factor, has previously been reportedto play an essential role in...
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Apoptosis in Ischemic Heart Disease
Ischemic heart disease (IHD) due to reduced coronary blood flow over a prolonged period as well as reperfusion of the ischemic myocardium are...
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Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
The transmembrane death receptor Fas transduces apoptotic signals upon binding its ligand, FasL. Although Fas is highly expressed in cancer cells,...
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Eltrombopag directly activates BAK and induces apoptosis
Small molecule direct BAK activators can potentially be used for the development of anti-cancer drugs or as tools to study BAK activation. The...
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Role of Cardiomyocyte Apoptosis in Heart Failure
Cardiomyocyte apoptosis has now been identified in a wide variety of patients with heart failure as well as in failing hearts due to experimentally...
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Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b
During the development of the vertebrate nervous system, 50% of the nerve cells undergo apoptosis shortly after formation. This process is important...
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CSE reduces OTUD4 triggering lung epithelial cell apoptosis via PAI-1 degradation
Ovarian tumor family deubiquitinase 4 (OTUD4), a member of the OTU deubiquitinating enzyme, is implicated to decrease in cancer to regulate cell...
