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Type I IFN-mediated regulation of IL-1 production in inflammatory disorders
Although contributing to inflammatory responses and to the development of certain autoimmune pathologies, type I interferons (IFNs) are used for the...
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Establishment of intestinal homeostasis during the neonatal period
The intestinal mucosa faces the challenge of regulating the balance between immune tolerance towards commensal bacteria, environmental stimuli and...
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Genome wide transcriptome profiling of a murine acute melioidosis model reveals new insights into how Burkholderia pseudomallei overcomes host innate immunity
BackgroundAt present, very little is known about how Burkholderia pseudomallei ( B. pseudomallei ) interacts with its host to elicit melioidosis...
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Evolution and functional divergence of NLRPgenes in mammalian reproductive systems
BackgroundNLRPs (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing Proteins) are members of NLR (Nod-like...
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A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish
BackgroundA large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis....
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High-Throughput RNAi Screen in Drosophila
Genetic and biochemical analyses in model systems such as the fruitfly, Drosophila melanogaster, have successfully identified several genes that play...
