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Establishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
Among mucus-producing lung cancers, invasive mucinous adenocarcinoma of the lung is a rare and unique subtype of pulmonary adenocarcinoma. Notably,...
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GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
Lung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migrating into...
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HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1
Lung adenocarcinoma (LUAD) is a fatal threat to human health, while the mechanism remains unclear, and the therapy brings limited therapeutic...
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Liquiritigenin Induces Cell Cycle Arrest and Apoptosis in Lung Squamous Cell Carcinoma
Liquiritigenin (LQ), as a dihydroflavone monomer compound extracted from Glycyrrhiza uralensis Fisch, has been demonstrated to show anti-tumor...
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Polymicrobial Biofilms in Cystic Fibrosis Lung Infections: Effects on Antimicrobial Susceptibility
Chronic lung infection is the main cause of morbidity and mortality in people with cystic fibrosis (CF). For many years, it was thought that...
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Andrographis modulates cisplatin resistance in lung cancer via miR-155-5p/SIRT1 axis
Andrographis (Andro) has been identified as an anti-cancer herbal. This study was to explore its underlying regulatory routes regarding cisplatin...
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The dynamic lung microbiome in health and disease
New methods and technologies within the field of lung biology are beginning to shed new light into the microbial world of the respiratory tract. Long...
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Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
Hypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma...
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Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression
BackgroundThe presence of mesenchymal stem cells has been confirmed in some solid tumors where they serve as important components of the tumor...
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Biodistribution of mesenchymal stromal cell-derived extracellular vesicles administered during acute lung injury
BackgroundMesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are a promising cell-free therapy for acute lung injury (ALI). To date,...
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Assessment of Lung Damage via Mitochondrial ROS Production Upon Chronic Exposure to Fipronil and Imidacloprid
Fipronil and imidacloprid are commonly used formulae in veterinary and agricultural sector. There are a few reports on their toxicological impact on...
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USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway
BackgroundWith the rapidly increasing morbidity and mortality, lung cancer has been considered one of the serious malignant tumors, affecting...
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Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer
The prognosis of lung cancer is poor with few effective therapies. Targeting ferroptosis is a new promising strategy for cancer therapy. LINC00641...
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Re-expression of epigenetically silenced PTPRR by histone acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2 inhibition
Silenced protein tyrosine phosphatase receptor type R (PTPRR) participates in mitogen-activated protein kinase (MAPK) signaling cascades during the...
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Prognostic biomarker discovery based on proteome landscape of Chinese lung adenocarcinoma
Despite recent innovations in imaging and genomic screening promotes advance in diagnosis and treatment of lung adenocarcinoma (LUAD), there remains...
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Role of STING in the treatment of non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various...
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A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer
Bone metastasis is one of the main complications of lung cancer and most important factors that lead to poor life quality and low survival rate in...
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IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
IntroductionInflammation plays a significant role in various cancers, including lung cancer, where the inflammatory cytokine IL-1β is often elevated...
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Modern therapies of nonsmall cell lung cancer
Lung cancer (LC), particularly nonsmall cell lung cancer (NSCLC), is one of the most prevalent types of neoplasia worldwide, regardless of gender,...
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Flt1 produced by lung endothelial cells impairs ATII cell transdifferentiation and repair in pulmonary fibrosis
Pulmonary fibrosis is a devastating disease, in which fibrotic tissue progressively replaces lung alveolar structure, resulting in chronic...
