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A high-resolution single-molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis
BackgroundAccurate and comprehensive annotation of transcript sequences is essential for transcript quantification and differential gene and...
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Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment
Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature...
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The divergence of alternative splicing between ohnologs in teleost fishes
BackgroundGene duplication and alternative splicing (AS) are two distinct mechanisms generating new materials for genetic innovations. The...
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A missense mutation in TTC8/BBS8 affecting mRNA splicing in patients with non-syndromic retinitis pigmentosa
Splicing disruption is one type of mutation mechanism for disease-predisposing alleles. To date, less than 30 mutations in TTC8/BBS8 have been...
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Revealing diverse alternative splicing variants of the highly homologous SMN1 and SMN2 genes by targeted long-read sequencing
The survival of motor neuron ( SMN ) genes, SMN1 and SMN2 , are two highly homologous genes related to spinal muscular atrophy (SMA). Different patterns...
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Form and Function of Tissues which Undergo Mineralization
The chapter presents aspects of the formation and development of the principal vertebrate mineralizing tissues, namely bone, calcifying cartilage,...
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Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping
Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9 and cytosine base editing (CBE) technologies,...
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Transcriptome profiling of longissimus dorsi during different prenatal stages to identify genes involved in intramuscular fat deposition in lean and obese pig breeds
BackgroundThere was significant difference in muscle development between fat-type and lean-type pig breeds.
Methods and resultsIn current study,...
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Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes
Progeroid syndromes such as Hutchinson Gilford Progeroid syndrome (HGPS), Werner syndrome (WS) and Cockayne syndrome (CS), result in severely reduced...
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Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells
BackgroundTransferrin receptor 1 (TfR1), encoded by TFRC , is a key regulator of iron homeostasis and plays important roles in many diseases,...
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Apical–basal polarity and the control of epithelial form and function
Epithelial cells are the most common cell type in all animals, forming the sheets and tubes that compose most organs and tissues. Apical–basal...
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Experimental Design for Time-Series RNA-Seq Analysis of Gene Expression and Alternative Splicing
RNA-sequencing (RNA-seq) is currently the method of choice for analysis of differential gene expression. To fully exploit the wealth of data...
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Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health
Alternative splicing (AS) regulates gene expression patterns at the post-transcriptional level and generates a striking expansion of coding...
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Genome sequencing-based transcriptomic analysis reveals novel genes in Peucedanum praeruptorum
BackgroundPeucedanum praeruptorum Dunn, a traditional Chinese herbal medicine, contains coumarin and volatile oil components that have clinical...
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Unique features of conventional and nonconventional introns in Euglena gracilis
BackgroundNuclear introns in Euglenida have been understudied. This study aimed to investigate nuclear introns in Euglenida by identifying a large...
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bHLH Transcription Factors Undergo Alternative Splicing During Cold Acclimation in a Eucalyptus hybrid
The basic-helix-loop-helix (bHLH) transcription factors superfamily is present in eukaryotes and has been widely characterized in several species....
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Mammalian C to U editing
The sequencing of genomes from higher organisms demonstrated that the number and complexity of expressed mRNA sequences and proteins exceeds the...
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Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing
Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases the complexity of gene expression programs, but is...
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Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige
Maintenance of oxygen homeostasis is an indispensable criterion for the existence of multicellular life-forms. Disruption of this homeostasis due to...
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Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing
It is estimated that 10%–30% of disease-associated genetic variants affect splicing. Splicing variants may generate deleteriously altered gene...
