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Combined melatonin-adipose derived mesenchymal stem cells therapy effectively protected the testis from testicular torsion-induced ischemia-reperfusion injury
BackgroundThis study tested the hypothesis that combined melatonin (Mel) and adipose-derived mesenchymal stem cells (ADMSCs) treatment was superior...
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Inactivation of testis-specific gene C4orf46 is dispensable for spermatogenesis and fertility in mouse
Several genes have been reported to be involved in spermatogenesis but their functional importance in male fertility is yet needed to be elucidated....
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Morphology of testis, sperm, and spermatheca in two capable hybridized termite species indicates no interspecific reproductive isolation
It would not surprise that two related termite species are similar in many traits, especially those related to reproduction such as similarity in...
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Dynamics of cattle sperm sncRNAs during maturation, from testis to ejaculated sperm
BackgroundDuring epididymal transit, spermatozoa go through several functional maturation steps, resulting from interactions with epididymal...
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The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription
Cancer-testis (CT) genes participate in the initiation and progression of cancer, but the role of CT-associated long non-coding RNAs (CT-lncRNAs) in...
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The cancer/testis antigen HORMAD1 mediates epithelial–mesenchymal transition to promote tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway in lung cancer
The cancer/testis antigen HORMAD1 is a mechanical regulator that modulates DNA homologous recombination repair and mismatch repair in multiple...
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Human placental mesenchymal stem cells ameliorate chemotherapy-induced damage in the testis by reducing apoptosis/oxidative stress and promoting autophagy
BackgroundThe side effects of busulfan on male reproduction are serious, so fertility preservation in children undergoing busulfan treatment is a...
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The effect of cyfluthrin on testis inhibin B in rats and the intervention of Lycium barbarum polysaccharide
BackgroundIn recent years, studies have shown that cyfluthrin is harmful to the reproductive system. Lycium barbarum polysaccharide may be a...
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An In Vitro Assay to Monitor Sertoli Cell Blood-Testis Barrier (BTB) Integrity
In this chapter, we detail a reliable, effective, and easy to perform assay to monitor the Sertoli cell blood–testis barrier (BTB) integrity. While...
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Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice
Numb (Nb) and Numb-like (Nbl) are functionally redundant adaptor proteins that critically regulate cell fate and morphogenesis in a variety of...
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Nanosized Titanium Dioxide Induced Apoptosis and Abnormal Expression of Blood-Testis Barrier Junction Proteins Through JNK Signaling Pathway in TM4 Cells
Nanosized titanium dioxide (nano-TiO 2 ) has been widely used in consumer products. It can cross the blood-testis barrier (BTB), and it has adverse...
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Cadmium Exposure and Testis Susceptibility: a Systematic Review in Murine Models
It is known that cadmium induces damage to the testis. However, the significant cadmium impact on the testicular architecture and the mechanisms...
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Recellularization of testicular feminization testis in C57bl6 as a natural bioreactor for creation of cellularized seminiferous tubules: an experimental study
We determined histological aspects of implanted human decellularized testicular matrix (DTM) in C57BL6 as a primitive step for further testis tissue...
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A comparative genomic approach using mouse and fruit fly data to discover genes involved in testis function in hymenopterans with a focus on Nasonia vitripennis
BackgroundSpermatogenesis appears to be a relatively well-conserved process even among distantly related animal taxa such as invertebrates and...
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The effect of sesame intake on adult albino rat testis during sildenafil long-term administration
BackgroundSildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies. Unfortunately, chronic...
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In Situ Hybridization of Estrogen Receptors α and β in the Human Testis
In situ hybridization (ISH)In situ hybridization (ISH) is an excellent method for detecting RNA in histological sections, both to detect gene...
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Effect of Nano-Titanium Dioxide on Blood-Testis Barrier and MAPK Signaling Pathway in Male Mice
Some studies have found that nano-sized titanium dioxide (nano-TiO 2 ) has adverse effects on the male reproductive system. Blood-testis barrier (BTB),...
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Protective Effect of Quercetin on Testis Structure and Apoptosis Against Lead Acetate Toxicity: an Stereological Study
Exposure to environmental pollutants tightly impacts on the male fertility. In the present study, we examined the toxic effects of lead acetate (Pb)...
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Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line
BackgroundThe increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic endocrine disruptors....
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Retinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms
Copper ionophore NSC319726 has attracted researchers' attention in treating diseases, particularly cancers. However, its potential effects on male...
