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Postbiotics Implication in the Microbiota-Host Intestinal Epithelial Cells Mutualism
To sustain host health and provide the microbial community with a nutrient-rich environment, the host and gut microbiota must interact with one...
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Impact of PepT1 deletion on microbiota composition and colitis requires multiple generations
Numerous studies of knockout mice find impacts on microbiota composition that influence host phenotype. However, such differences can vanish when KO...
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Identification of the pyroptosis‑related prognostic gene signature and the associated regulation axis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) remains the most common deadly disease and has a poor prognosis. Pyroptosis could regulate tumour cell proliferation,...
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Bacteroides uniformis-induced perturbations in colonic microbiota and bile acid levels inhibit TH17 differentiation and ameliorate colitis developments
Inflammatory bowel disease (IBD) is associated with gut dysbiosis and can lead to colitis-associated malignancies. Bacteroides uniformis (Bu)...
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Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice
Iron is an important micronutrient that plays a vital role in host defenses and bacterial pathogenicity. As iron treatments increase the risk of...
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Siah2–GRP78 interaction regulates ROS and provides a proliferative advantage to Helicobacter pylori-infected gastric epithelial cancer cells
Helicobacter pylori -mediated gastric carcinogenesis involves upregulation of the E3 ubiquitin ligase Siah2 and its phosphorylation-mediated...
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Adipose-derived stem cells alleviate liver injury induced by type 1 diabetes mellitus by inhibiting mitochondrial stress and attenuating inflammation
BackgroundType 1 diabetes mellitus (T1D) is a worldwide health priority due to autoimmune destruction and is associated with an increased risk of...
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Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease
Liver disease, a major health concern worldwide, is a serious and progressive disorder. Herein, we not only established a mouse model of DEN+CCl 4 -indu...
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Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases
Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive inflammation are responsible for the occurrence and...
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LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
Ischemia-reperfusion (I/R) is a common pathology when the blood supply to an organ was disrupted and then restored. During the reperfusion process,...
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ATP-binding and hydrolysis of human NLRP3
The innate immune system uses inflammasomal proteins to recognize danger signals and fight invading pathogens. NLRP3, a multidomain protein belonging...
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Epigenetic regulation of functional candidate genes for milk production traits in dairy sheep subjected to protein restriction in the prepubertal stage
BackgroundAs the prepubertal stage is a crucial point for the proper development of the mammary gland and milk production, this study aims to...
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Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease
Irisin protects the cardiovascular system against vascular diseases. However, its role in chronic kidney disease (CKD) -associated vascular...
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Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
BackgroundThe coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore...
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Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases
The ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD)) protein is an scaffold component of different...
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A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer
Ovarian cancer (OC) is a highly malignant gynaecological tumour that has a very poor prognosis. Pyroptosis has been demonstrated in recent years to...
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Pyroptosis in neurodegenerative diseases: from bench to bedside
The central nervous system regulates all aspects of physiology to some extent. Neurodegenerative diseases (NDDs) lead to the progressive loss and...
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Heminiphilus faecis gen. nov., sp. nov., a member of the family Muribaculaceae, isolated from mouse faeces and emended description of the genus Muribaculum
The novel strain AM35 T was isolated from the faeces of C57BL/6 mice. These cells are strictly anaerobic, gram negative, oxidase negative, catalase...
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Single-Cell Studies of Intestinal Stem Cell Heterogeneity During Homeostasis and Regeneration
Single-cell RNA-sequencing (scRNA-seq) provides a unique opportunity to study heterogeneous cell populations within tissues, including the intestinal...
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The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies
Immunotherapy is one of the fastest developing areas in the field of oncology. Many immunological treatment strategies for refractory tumors have...
