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Anti-Osteoarthritic Effects of Cartilage-Derived Extracellular Matrix in a Rat Osteoarthritis Model
BACKGROUND: The extracellular matrix (ECM) has many functions, such as segregating tissues, providing support, and regulating intercellular...
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Characterization of exosomal long non-coding RNAs in chondrogenic differentiation of human adipose-derived stem cells
The exosomes derived from chondrogenic stem cells and long non-coding RNAs (lncRNAs) play a key role in cartilage regeneration. Here, we investigated...
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MicroRNA-128a represses chondrocyte autophagy and exacerbates knee osteoarthritis by disrupting Atg12
Chondrocyte loss is a prominent feature of osteoarthritis (OA). Autophagy is indispensable in maintaining the metabolic activities of cells exposed...
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Transplantation of Gelatin Microspheres Loaded with Wharton's Jelly Derived Mesenchymal Stem Cells Facilitates Cartilage Repair in Mice
Background:Knee osteoarthritis (KOA) is a prevalent chronic joint disease caused by various factors. Mesenchymal stem cells (MSCs) therapy is an...
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Culture and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells on Growth Factor-Rich Fibrin Scaffolds to Produce Engineered Cartilages
Introduction After injuries, the cartilage healing capacity is limited owing to its nature as a particular connective tissue without blood vessels,...
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Determining the Notch1 Expression in Chondrogenically Differentiated Rat Amniotic Fluid Stem Cells in Alginate Beads Using Conditioned Media from Chondrocytes Culture
AbstractThe molecular mechanisms involved in the progression of chondrogenic differentiation require considerable studies, despite significant...
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Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
Human skin uses millions of hairs and glands distributed across the body surface to function as an external barrier, thermoregulator and stimuli...
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RGS12 is required for the maintenance of mitochondrial function during skeletal development
Mitochondrial morphology and function are crucial for tissue homeostasis, such as for skeletal development, but the cellular and molecular mechanisms...
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Transplantation of ASCs-Poly (ε-Caprolactone) Nanofiber Scaffold and Evaluate the Effect of Mechanical Loading of Walking on Articular Cartilage Repair in Sheep Model
AbstractMechanical loading influences on the chondrocyte and may promote articular cartilage repair in vivo. That is thought to play a key role in...
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Genome-wide identification and expression analysis of Dmrt genes in bivalves
In recent years, some common themes in the development of sex-specific traits in different animal lineages have started to emerge since the discovery...
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Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA,...
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Characterization of Tendon-Derived Stem Cells and Rescue Tendon Injury
The natural healing ability of tendon is limited, and it cannot restore the native structure and function of tendon injuries. Tendon-derived stem...
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The emerging studies on mesenchymal progenitors in the long bone
Mesenchymal progenitors (MPs) are considered to play vital roles in bone development, growth, bone turnover, and repair. In recent years, benefiting...
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Characterization of sexual size dimorphism and sex-biased genes expression profile in the olive flounder
Sexual size dimorphism (SSD) is a widespread phenomenon in fish species, including in the olive flounder. Although it is well established that female...
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CD317+ MSCs expanded with chemically defined media have enhanced immunological anti-inflammatory activities
BackgroundAlthough both preclinical and clinical studies have shown the great application potential of MSCs (mesenchymal stem/stromal cells) in...
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Lysosome-targeted ruthenium(II) complex encapsulated with pluronic® F-127 induces oncosis in A549 cells
Transition metal complexes with characteristics of unique packaging in nanoparticles and remarkable cancer cell cytotoxicity have emerged as...
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Toll-like receptor activation regulates the paracrine effect of adipose-derived mesenchymal stem cells on reversing osteoarthritic phenotype of chondrocytes
BackgroundThe therapeutic efficacy of intra-articular mesenchymal stem cells (MSCs) injection for patients with osteoarthritis (OA) currently...
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Stem Cell-Based Regeneration of Salivary Glands: From Bench to Clinics
Exocrine gland regeneration, particularly salivary gland regeneration, remains an exciting arena for the scientific world due to its crucial role in...
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Stem Cell-Based Regeneration of Salivary Glands: From Bench to Clinics
Exocrine gland regeneration, particularly salivary gland regeneration, remains an exciting arena for the scientific world due to its crucial role in...
