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Microbiome in Asthma
Asthma is a prevalent persistent pulmonary illness that affects people all over the world. It affects people of all ages, although it is more common...
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Inflammasome activation and regulation: toward a better understanding of complex mechanisms
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter...
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NLRP3 inflammasome in endothelial dysfunction
Inflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate immune signal receptors to sense pathogens and initiate...
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Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches
AbstractUveal melanoma (UM) is a neuroectodermal tumor that results from malignant transformation of melanocytes in the eye uvea, including the iris,...
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Pyroptotic cell death: an emerging therapeutic opportunity for radiotherapy
Pyroptotic cell death, an inflammatory form of programmed cell death (PCD), is emerging as a potential therapeutic opportunity for radiotherapy (RT)....
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Gut Microbiota Dysbiosis and Increased NLRP3 Levels in Patients with Pregnancy-Induced Hypertension
Pregnancy-induced hypertension (PIH) is one of the most common diseases, causing high maternal morbidity and mortality. However, the correlation of...
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Spatial discordances between mRNAs and proteins in the intestinal epithelium
The use of transcriptomes as reliable proxies for cellular proteomes is controversial. In the small intestine, enterocytes operate for 4 days as they...
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A Critical Review on Akkermansia muciniphila: Functional Mechanisms, Technological Challenges, and Safety Issues
Due to its physiological benefits from in vitro and in vivo points of view, Akkermansia muciniphila , a common colonizer in the human gut mucous...
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Genome-wide association study for stayability at different calvings in Nellore beef cattle
BackgroundingStayability, which may be defined as the probability of a cow remaining in the herd until a reference age or at a specific number of...
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Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment
Interleukin (IL)-18, a member of the IL-1 family of cytokines, has emerged as a key regulator of mucosal homeostasis within the gastrointestinal...
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Intestinal microbiota: a new force in cancer immunotherapy
Cancer displays high levels of heterogeneity and mutation potential, and curing cancer remains a challenge that clinicians and researchers are eager...
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The m6A methylation and expression profiles of mouse neural stem cells after hypoxia/reoxygenation
BackgroundIschemia–reperfusion injury to the central nervous system often causes severe complications. The activation of endogenous neural stem cells...
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Interaction between microbiota and immunity in health and disease
The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in...
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Pyroptosis and degenerative diseases of the elderly
Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling...
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The emerging role of regulated cell death in ischemia and reperfusion-induced acute kidney injury: current evidence and future perspectives
Renal ischemia‒reperfusion injury (IRI) is one of the main causes of acute kidney injury (AKI), which is a potentially life-threatening condition...
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Microbiome-based therapeutics
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing susceptibility to infection and enhancing resistance to a...
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Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis
Ulcerative colitis (UC) is a significant inflammatory bowel disease caused by an abnormal immune response to gut microbes. However, there are still...
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NAIP expression increases in a rat model of liver mass restoration
The neuronal apoptosis inhibitory protein (NAIP) is a constituent of the NLRC4 inflammasome, which plays a key role in innate immunity, and an...
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Multifaceted Functions of RNA m6A Modification in Modulating Regulated Cell Death
Cell death is attributed to the unrecoverable disturbance of cells exposed to intracellular or extracellular stimulus. Regulated cell death (RCD),...
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Diagnostic and prognostic values of pyroptosis-related genes for the hepatocellular carcinoma
BackgroundDue to the high heterogeneity, the early diagnosis and prognostic prediction of hepatic cellular cancer (HCC) is challenging. In this...
