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An NADPH oxidase regulates carbon metabolism and the cell cycle during root nodule symbiosis in common bean (Phaseolus vulgaris)
BackgroundRhizobium–legume symbiosis is a specific, coordinated interaction that results in the formation of a root nodule, where biological nitrogen...
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Monoamine oxidase mediated oxidative stress: a potential molecular and biochemical crux in the pathogenesis of obesity
Obesity has become a global health concern with an increasing prevalence as years pass by but the researchers have not come to a consensus on the...
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PKCζ–NADPH Oxidase–PKCα Dependent Kv1.5 Phosphorylation by Endothelin-1 Modulates Nav1.5–NCX1–Cav1.2 Axis in Stimulating Ca2+ Level in Caveolae of Pulmonary Artery Smooth Muscle Cells
Endothelin-1 (ET-1) is a potent endogenously derived vasoconstrictor, which increases pulmonary hypertension via stimulation of [Ca 2+ ] i level in...
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Upregulated expression of RESPIRATORY BURST OXIDASE HOMOLOG D underlies lesion-mimic phenotype in dark-treated Arabidopsis pheide a oxygenase mutant leaves
Main conclusionUpregulated expression of RESPIRATORY BURST OXIDASE HOMOLOG D ( RBOHD ) encoding a plasma membrane NADPH oxidase is responsible for the...
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Assessment of the Peroxisomal Redox State in Living Cells Using NADPH- and NAD+/NADH-Specific Fluorescent Protein Sensors
The pyridine nucleotides NAD(H) and NADP(H) are key molecules in cellular metabolism, and measuring their levels and oxidation states with...
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Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis
Oncogenic RAS is a critical driver for the initiation and progression of several types of cancers. However, effective therapeutic strategies by...
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Apocynin ameliorates NADPH oxidase 4 (NOX4) induced oxidative damage in the hypoxic human retinal Müller cells and diabetic rat retina
NADPH oxidase (NOX) is a main producers of reactive oxygen species (ROS) that may contribute to the early pathogenesis of diabetic retinopathy (DR)....
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Quantitative Analysis for ROS-Producing Activity and Regulation of Plant NADPH Oxidases in HEK293T Cells
Reactive oxygen species (ROS) produced by plant NADPH oxidases, respiratory burst oxidase homologs (RBOHs), play key roles in biotic and abiotic...
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Effects of redox modulation on quiescin/sulfhydryl oxidase activity of melanoma cells
Secreted quiescin/sulfhydryl oxidase (QSOX) is overexpressed in many tumor cell lines, including melanoma, and is usually associated with a...
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NADPH production in dark stages is critical for cyanobacterial photocurrent generation: a study using mutants deficient in oxidative pentose phosphate pathway
Live cyanobacteria and algae integrated onto an extracellular electrode can generate a light-induced current (i.e., a photocurrent). Although the...
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Tools to Identify Noxes and their Regulators
The family of NADPH oxidases consists of at least 7 members: Nox1, Nox2, Nox3 Nox4, Nox5, Duox1 and Duox2. The sole function of all NADPH oxidases...
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NADPH-Oxidasen und HIF: zentrale Elemente der Redoxhomöostase
Reactive oxygen species (ROS) are not only toxic agents but also potent signaling molecules. NADPH oxidases are the sole enzymes to generate ROS...
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Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure
BackgroundOxidative stress is implicated in the pathogenesis of heart failure. Dual oxidase 1 (DUOX1) might be important in heart failure development...
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The Discovery and Characterisation of Nox2, a Personal Journey
This chapter describes the discovery of the nature of the neutrophil NADPH oxidase and the causes of Chronic Granulomatous disease (CGD), the...
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Nox5: Molecular Regulation and Pathophysiology
Nox5 is considered to be the precursor NADPH oxidase in the evolution of the Noxs and is the most ancient member of the Nox family. It is widely...
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High Salinity Stimulates the Adaptive Response to Potassium Deficiency Through the Antioxidant and the NADPH-Generating Systems in the Roots and Leaves of the Halophyte Cakile maritima
Salinity is one of the most constraining environmental factors that limits plant growth and productivity because it disturbs mineral nutrition by...
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Paradigm Shifts in the History of Nox2 and Its Regulators: An Appreciative Critique
This chapter narrates the history of the almost a century-long work on the phagocyte NADPH oxidase, from the first report on the “respiration” of dog...
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History and Discovery of the Noxes: From Nox1 to the DUOXes
Aerobic organisms have adapted to living in an oxygen-rich environment by using the chemical energy of molecular oxygen (O2). In addition to...
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Chronic Granulomatous Disease
Chronic granulomatous disease (CGD) is an immunodeficiency that affects phagocytic leukocytes (neutrophils, monocytes, macrophages and eosinophils)....
