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Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling
BackgroundMice with a loss of function mutation in Wdpcp were described previously to display severe birth defects in the developing heart, neural...
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Elektrische Charakterisierung von Eizellen mit mikrofluidischen Systemen
In in vitro fertilization, the status of the zona pellucida is of pivotal interest to determine the window of best fertilization. In this window, the...
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Extracellular matrix derived by human umbilical cord-deposited mesenchymal stem cells accelerates chondrocyte proliferation and differentiation potential in vitro
The extracellular matrix (ECM) is a dynamic and intricate three-dimensional (3D) microenvironment with excellent biophysical, biomechanical, and...
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Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel
BackgroundMesenchymal stem cells are a promising cell source for chondrogenic differentiation and have been widely used in several preclinical and...
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Articular Cartilage Regeneration in Veterinary Medicine
Cartilage is an avascular tissue with a limited rate of oxygen and nutrient diffusion, resulting in its inability to heal spontaneously. Articular...
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A call for standardization for secretome and extracellular vesicles in osteoarthritis: results show disease-modifying potential, but protocols are too heterogeneous—a systematic review
The currently available osteoarthritis (OA) treatments offer symptoms’ relief without disease-modifying effects. Increasing evidence supports the...
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In vivo potency assay for the screening of bioactive molecules on cartilage formation
Cartilage regeneration is a priority in medicine for the treatment of osteoarthritis and isolated cartilage defects. Several molecules with potential...
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Bioactivity of human adult stem cells and functional relevance of stem cell-derived extracellular matrix in chondrogenesis
BackgroundAutologous chondrocyte implantation (ACI) has been used to treat articular cartilage defects for over two decades. Adult stem cells have...
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Single-Cell Analysis Approaches in Cartilage Diseases Diagnosis and Therapies
Substantial evidence shows that major breakthrough toward cartilage therapeutic approaches is largely hampered by the low chondrocytes yield along...
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Polyvinylamine and Its Derivative as Effective Carrier for Targeted Delivery of Small RNAs
Polymeric delivery systems could enable the fast- and low-side-effect transport of various RNA classes. Previously, we demonstrated that...
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Culture and characterization of various porcine integumentary-connective tissue-derived mesenchymal stromal cells to facilitate tissue adhesion to percutaneous metal implants
BackgroundTransdermal osseointegrated prosthesis have relatively high infection rates leading to implant revision or failure. A principle cause for...
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Validation of Tissue-Engineered Constructs: Preclinical and Clinical Studies
The weak self-regeneration ability of articular cartilage following injury and the unacceptable results of traditional clinical necessitate...
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Preclinical functional characterization methods of nanocomposite hydrogels containing silver nanoparticles for biomedical applications
Nanocomposite hydrogels that contain silver nanoparticles (AgNPs) are especially attractive for various biomedical applications (e.g., antimicrobial...
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The Dysregulated Galectin Network Activates NF-κB to Induce Disease Markers and Matrix Degeneration in 3D Pellet Cultures of Osteoarthritic Chondrocytes
This work aimed to study the dysregulated network of galectins in OA chondrocyte pellets, and to assess whether their recently discovered activity as...
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Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the major source of pain and...
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iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review
Cartilage, an important connective tissue, provides structural support to other body tissues, and serves as a cushion against impacts throughout the...
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Insights into the present and future of cartilage regeneration and joint repair
Knee osteoarthritis is the most common joint disease. It causes pain and suffering for affected patients and is the source of major economic costs...
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Characterization of exosomal long non-coding RNAs in chondrogenic differentiation of human adipose-derived stem cells
The exosomes derived from chondrogenic stem cells and long non-coding RNAs (lncRNAs) play a key role in cartilage regeneration. Here, we investigated...
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Tissue Reconstructive and Regenerative Medicine Approach as an Anti-Aging Intervention: Relevance to Age-Induced Osteoarthritis
Aging is a dynamic, irreversible, and inevitable physiological process associated with gradual deterioration in the overall performance of all the...
