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Alternative splicing analysis of lignocellulose-degrading enzyme genes and enzyme variants in Aspergillus niger
AbstractAlternative splicing (AS) greatly expands the protein diversity in eukaryotes. Although AS variants have been frequently reported existing in...
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Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial–mesenchymal transition of breast cancer cells
Ubiquitin-specific protease (USP)19 is a deubiquitinating enzyme that regulates the stability and function of multiple proteins, thereby controlling...
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Alternative splicing coupled to nonsense-mediated decay coordinates downregulation of non-neuronal genes in developing mouse neurons
BackgroundThe functional coupling between alternative pre-mRNA splicing (AS) and the mRNA quality control mechanism called nonsense-mediated decay...
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Alternative Splicing in Human Biology and Disease
Alternative pre-mRNA splicing allows for the production of multiple mRNAs from an individual gene, which not only expands the protein-coding...
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Modulatory role of RNA helicases in MBNL-dependent alternative splicing regulation
Muscleblind-like splicing regulators (MBNLs) activate or repress the inclusion of alternative splicing (AS) events, enabling the developmental...
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Insights into sweet potato SR proteins: from evolution to species-specific expression and alternative splicing
Main conclusionSR proteins from sweet potato have conserved functional domains and similar gene structures as that of Arabidopsis and rice in...
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Single-molecule long-read sequencing analysis improves genome annotation and sheds new light on the transcripts and splice isoforms of Zoysia japonica
BackgroundZoysia japonica is an important warm-season turfgrass used worldwide. Although the draft genome sequence and a vast amount of...
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Integrated omics analysis identified genes and their splice variants involved in fruit development and metabolites production in Capsicum species
To date, several transcriptomic studies during fruit development have been reported; however, no comprehensive integrated study on expression...
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2passtools: two-pass alignment using machine-learning-filtered splice junctions increases the accuracy of intron detection in long-read RNA sequencing
Transcription of eukaryotic genomes involves complex alternative processing of RNAs. Sequencing of full-length RNAs using long reads reveals the true...
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HA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
G protein-coupled receptors (GPCRs) are notoriously difficult to detect in native tissues. In an effort to resolve this problem, we have developed a...
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SRSF1 is essential for primary follicle development by regulating granulosa cell survival via mRNA alternative splicing
Granulosa cell abnormalities are characteristics of premature ovarian insufficiency (POI). Abnormal expression of serine/arginine-rich splicing...
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The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression
Intersectin 1 (ITSN1) contains two isoforms: ITSN1-S and ITSN1-L, which are highly regulated by alternative splicing. Our previous results showed...
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State-of-the-Art Circular RNA Analytics Using the Circtools Software Suite
Circular RNAs (circRNAs) are types of RNA molecules that have been discovered relatively recently and have been found to be widely expressed in...
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The SWI/SNF subunit BRG1 affects alternative splicing by changing RNA binding factor interactions with nascent RNA
BRG1 and BRM are ATPase core subunits of the human SWI/SNF chromatin remodelling complexes mainly associated with transcriptional initiation. They...
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A web-based database server using 43,710 public RNA-seq samples for the analysis of gene expression and alternative splicing in livestock animals
BackgroundLivestock animals is of great significance in agricultural production. However, the role of specific gene expression, especially...
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Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes
Emerging evidence points towards a regulatory role of the circadian clock in alternative splicing (AS). Whether alterations in core-clock components...
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Possible Contribution of Alternative Transcript Isoforms in Mature Biofilm Growth Phase of Candida glabrata
Expression of genome-wide alternative transcript isoforms and differential transcript isoform usage in different biological conditions (isoform...
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Genome-wide identification of associations between enhancer and alternative splicing in human and mouse
BackgroundAlternative splicing (AS) increases the diversity of transcriptome and could fine-tune the function of genes, so that understanding the...
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Characteristics of RNA alternative splicing and its potential roles in ginsenoside biosynthesis in a single plant of ginseng, Panax ginseng C.A. Meyer
RNA alternative splicing (AS) is prevalent in higher organisms and plays a paramount role in biology; therefore, it is crucial to have comprehensive...
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Targeting Alternative Splicing for Therapeutic Interventions
Targeting of pre-mRNA splicing has yielded a rich variety of strategies for altering gene expression as a treatment for disease. The search for...
