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Octanoic acid mitigates busulfan-induced blood-testis barrier damage by alleviating oxidative stress and autophagy
BackgroundThe management of male infertility continues to encounter an array of challenges and constraints, necessitating an in-depth exploration of...
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Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis
BackgroundCancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for...
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Transcriptome analysis revealed gene expression feminization of testis after exogenous tetrodotoxin administration in pufferfish Takifugu flavidus
Tetrodotoxin (TTX) is a deadly neurotoxin and usually accumulates in large amounts in the ovaries but is non-toxic or low toxic in the testis of...
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Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility
BackgroundFascins belong to a family of actin-bundling proteins that are involved in a wide range of biological functions. FSCN3, a newly identified...
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Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously...
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Autophagy is required for spermatogonial differentiation in the Drosophila testis
Autophagy is a conserved, lysosome-dependent catabolic process of eukaryotic cells which is involved in cellular differentiation. Here, we studied...
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Transcriptomes of Testes at Different Developmental Stages in the Opsariichthys bidens Predict Key Genes for Testis Development and Spermatogenesis
Testis development is a complex process involving multiple genes, and the molecular mechanisms underlying testis development in Opsariichthys bidens ...
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Streptococcus canis prostatitis and endocarditis with thromboembolism in a dog with sertoli cell tumour in a cryptic testis and prostatic squamous metaplasia
We describe an unusual case of prostatitis caused by Streptococcus canis evolving to endocarditis and splenic, renal, and cerebral thromboembolism in...
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Liposome-Encapsulated Rec8 and Dmrt1 Plasmids Induce Red-Spotted Grouper (Epinephelus akaara) Testis Maturation
In fish, the maturity of gonads plays an important role in the development and reproduction of the population, and it also dictates the success of...
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Primary Cultures of Spermatogonia and Testis Cells
Spermatogonial stem cells (SSCs) maintain adult spermatogenesis in mammals by undergoing self-renewal and differentiation into spermatozoa. In order...
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Maternal Fed Zinc-Deficient Diet: Effects on Relaxin Family Peptides and Oxidant System in the Testis and Liver Tissue of Male Offspring
Today, the studies are limited on roles of insulin-like peptide 3 (INSL3), insulin-like peptide 7 (INSL7), and relaxin family peptide receptor 1...
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AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility
Spermiogenesis is a complex process depending on the sophisticated coordination of a myriad of testis-enriched gene regulations. The regulatory...
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The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice
BackgroundUbiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such...
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Localization and regulatory function of Yin Yang 1 (YY1) in chicken testis
In mammals, Yin Yang 1 (YY1), a pervasively expressed transcription factor related to many biological processes as an activator or inhibitor of the...
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Microinjection of antisense oligonucleotides into living mouse testis enables lncRNA function study
BackgroundLong non-coding RNAs (lncRNAs) have been the focus of ongoing research in a diversity of cellular processes. LncRNAs are abundant in...
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Ex-Vivo and In-Vivo Expansion of Spermatogonial Stem Cells Using Cell-Seeded Microfluidic Testis Scaffolds and Animal Model
AimsThis study was designed to provide both ex-vivo and in-vivo methods for the extraction and expansion of spermatogonial stem cells (SSCs).
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The Effects of Chronic Lead Exposure on Testicular Development of Japanese Quail (Coturnix japonica): Histopathological Damages, Oxidative Stress, Steroidogenesis Disturbance, and Hypothalamus-Pituitary-Testis Axis Disruption
Lead (Pb) becomes a global public health concern for its high toxicology. Birds are sensitive to environmental pollution and Pb contamination exerts...
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The molecular regulation mechanism of dmrt1—based on the establishment of the testis cell line derived from two-spot puffer Takifugu bimaculatus
The establishment of fish cell lines can provide an important in vitro model for developmental biology, pathology, and genetics and also an effective...
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Transcriptome analysis reveals differentially expressed genes between the ovary and testis of the honey bee Apis mellifera
Honey bees ( Apis mellifera ) are an important social pollinator, crucial in maintaining ecological balance and biodiversity. The haploid-diploid sex...
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ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity
BackgroundRNA N 6 -methyladenosine (m 6 A) is involved in mammalian spermatogenesis. In both germ cells and Leydig cells, ALKBH5 regulates...
