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DExD/H-box helicases: multifunctional regulators in antiviral innate immunity
DExD/H-box helicases play critical roles in multiple cellular processes, including transcription, cellular RNA metabolism, translation, and...
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Interactions of Microbiome for Gut-Brain Axis Health
The various types of interactions between the gut microbes and the brain have engrossed the interest of researchers in recent times in the context of...
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Amyloid-β mediates intestinal dysfunction and enteric neurons loss in Alzheimer's disease transgenic mouse
Alzheimer's disease (AD) is traditionally considered as a brain disorder featured by amyloid-β (Aβ) deposition. The current study on whether...
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NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
BackgroundMembers of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various...
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Ubiquitin-specific proteases in inflammatory bowel disease-related signalling pathway regulation
The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal inflammatory disease comprising Crohn’s disease and ulcerative...
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Phase separation-mediated biomolecular condensates and their relationship to tumor
Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets"...
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Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma
Programmed cell death (PCD) resistance is a key driver of cancer occurrence and development. The prognostic relevance of PCD-related genes in...
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ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction
Z-DNA binding protein 1 (ZBP1) is a crucial player in the intracellular recognition of Z-form nucleic acids (Z-NAs) through its Zαβ domain,...
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Divergent functions of NLRP3 inflammasomes in cancer: a review
The cancer is a serious health problem, which is The cancer death rate (cancer mortality) is 158.3 per 100,000 men and women per year (based on...
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The inflammatory signature in monocytes of Sjögren’s syndrome and systemic lupus erythematosus, revealed by the integrated Reactome and drug target analysis
BackgroundThe innate immune regulation, especially by the type I IFN signature in the CD14+ monocytes, is known to be critical in the pathogenesis of...
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Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges
As one of the promising next-generation probiotics (NGPs), Akkermansia muciniphila , a well-known mucin-degrading bacterium, has been proven to be...
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The potential of Akkermansia muciniphila in inflammatory bowel disease
AbstractAkkermansia muciniphila is a next-generation probiotic with significant application prospects. The role of A. muciniphila in metabolic...
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Endogenous bioluminescent reporters reveal a sustained increase in utrophin gene expression upon EZH2 and ERK1/2 inhibition
Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by loss of function mutations in the dystrophin gene ( Dmd ), resulting in progressive...
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Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle
Feed-efficient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difficulties in...
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Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis
BackgroundUlcerative colitis (UC) refers to an intractable intestinal inflammatory disease. Its increasing incidence rate imposes a huge burden on...
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cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation
BackgroundIntracellular DNA-sensing pathway cGAS-STING, inflammasomes and pyroptosis act as critical natural immune signaling axes for microbial...
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Caspase-4 Activation and Recruitment to Intracellular Gram-Negative Bacteria
The non-canonical inflammasome pathway functions as the primary cytosolic innate immune detection mechanism for Gram-negative bacterial...
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Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response
Inflammatory bowel disease could be induced by SARS-CoV-2, involved in alteration of gut microbiota during the respiratory viral infection. Presence...
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The crosstalk between enteric nervous system and immune system in intestinal development, homeostasis and diseases
The gut is the largest digestive and absorptive organ, which is essential for induction of mucosal and systemic immune responses, and maintenance of...
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Gut microbiota and the human gut physiological changes
BackgroundThe human gut can be colonized by number of microorganisms. The most studied are bacteria, which changes from birth to newborn born into...
