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Lung Organoids: A New Pathway into Lung Regeneration and Repair
Introduction: The lung is an important and complicated organ that has profound impacts on the entire body when impacted by disease or illness. Due to...
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Repurposing Decellularized Lung to Generate Vascularized Fat
Conventional therapies to address critically sized defects in subcutaneous adipose tissue remain a reconstructive challenge for surgeons, largely due...
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Metagenomic sequencing reveals swine lung microbial communities and metagenome-assembled genomes associated with lung lesions—a pilot study
Low microbial biomass in the lungs, high host-DNA contamination and sampling difficulty limit the study on lung microbiome. Therefore, little is...
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RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore,...
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Exploring Co-occurrence patterns and microbial diversity in the lung microbiome of patients with non-small cell lung cancer
BackgroundIt has been demonstrated in the literature that a dysbiotic microbiome could have a negative impact on the host immune system and promote...
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An Introduction to Engineering and Modeling the Lung
Over the last decade, the field of lung biology has evolved considerably due to many advancements, including the advent of single-cell RNA (scRNA)...
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Assessment of Collagen in Translational Models of Lung Research
The extracellular matrix (ECM) plays an important role in lung health and disease. Collagen is the main component of the lung ECM, widely used for...
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Introduction to Lung Disease
The global incidence of lung disease (LD) affecting children and adults is steadily increasing. The source of mortality and morbidity of lung...
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Rolapitant treats lung cancer by targeting deubiquitinase OTUD3
BackgroundLung cancer is cancer with the highest morbidity and mortality in the world and poses a serious threat to human health. Therefore,...
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Mendelian randomization analyses explore the relationship between cathepsins and lung cancer
Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex pathogenesis. Cathepsins, lysosomal cysteine proteases,...
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The Role of Macrophages in Lung Fibrosis and the Signaling Pathway
Lung fibrosis is a dysregulated repair process caused by excessive deposition of extracellular matrix that can severely affect respiratory function....
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Pathogenesis of ventilator-induced lung injury: metabolomics analysis of the lung and plasma
IntroductionNowadays,the mechanical ventilation (MV) aims to rest the respiratory muscles while providing adequate gas exchange, and it has been a...
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Nontuberculous Mycobacterium Infections in Lung Disease and Medical Interventions
Infection with nontuberculous mycobacteria (NTM) is on the rise all across the world. Lung disease due to NTM is more prevalent and frequent and is...
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Assessing lung consolidation in goats using different ultrasonographic techniques
Goats are often affected by respiratory diseases and, despite ultrasonography can assess lung consolidations in several species, it is rarely used in...
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Transcriptomic analysis of lung development in wildtype and CFTR−/− sheep suggests an early inflammatory signature in the CF distal lung
The precise molecular events initiating human lung disease are often poorly characterized. Investigating prenatal events that may underlie lung...
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Anti-CCL2 therapy reduces oxygen toxicity to the immature lung
Oxygen toxicity constitutes a key contributor to bronchopulmonary dysplasia (BPD). Critical step in the pathogenesis of BPD is the inflammatory...
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Guggulsterone protects against cigarette smoke-induced COPD linked lung inflammation
Recently, we have shown that guggulsterone is the principal constituent responsible for protective effects of Commiphora wightii against...
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miRNA as biomarker in lung cancer
Lung cancer has a high prevalence and mortality due to its late diagnosis and limited treatment, so it is essential to find biomarkers that allow a...
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DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by...
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FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression
FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the...
