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Spliceator: multi-species splice site prediction using convolutional neural networks
BackgroundAb initio prediction of splice sites is an essential step in eukaryotic genome annotation. Recent predictors have exploited Deep Learning...
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eEF1A1 regulates the expression and alternative splicing of genes associated with Parkinson’s disease in U251 cells
BackgroundEukaryotic elongation factor 1A1 (eEF1A1) is an RNA-binding protein that is associated with PARK2 activity in cells, suggesting a possible...
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Comprehensive deciphering the alternative splicing patterns involved in leaf morphogenesis of Liriodendron chinense
Alternative splicing (AS), a pivotal post-transcriptional regulatory mechanism, profoundly amplifies diversity and complexity of transcriptome and...
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Analysis of CCR2 splice variant expression patterns and functional properties
BackgroundC–C motif chemokine receptor 2 (CCR2), the main receptor for monocyte chemoattractant protein-1 (MCP-1), is expressed on immune cells,...
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The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway....
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Identification of cell-type specific alternative transcripts in the multicellular alga Volvox carteri
BackgroundCell type specialization is a hallmark of complex multicellular organisms and is usually established through implementation of...
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The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a myriad of ways. Here, we...
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Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing
Talaromyces marneffei ( T. marneffei ) immune escape is essential in the pathogenesis of talaromycosis. It is currently known that T. marneffei ...
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Alternative Splicing Reveals Acute Stress Response of Litopenaeus vannamei at High Alkalinity
Alkalinity is regarded as one of the primary stressors for aquatic animals in saline-alkaline water. Alternative splicing (AS) can significantly...
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Wheat Pm4 resistance to powdery mildew is controlled by alternative splice variants encoding chimeric proteins
Crop breeding for resistance to pathogens largely relies on genes encoding receptors that confer race-specific immunity. Here, we report the...
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Alternative splicing is not a key source of chemerin isoforms diversity
BackgroundChemerin is a chemoattractant protein with adipokine and antimicrobial properties encoded by the retinoic acid receptor responder 2 ( RARRES2...
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Effects of Gene Alternative Splicing Events on Resistance to Cryptocaryonosis of Large Yellow Croaker (Larimichthys crocea)
Large yellow croaker ( L. crocea ) is a productive species in marine aquaculture with great economic value in China. However, the sustainable...
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SimSpliceEvol2: alternative splicing-aware simulation of biological sequence evolution and transcript phylogenies
BackgroundSimSpliceEvol is a tool for simulating the evolution of eukaryotic gene sequences that integrates exon-intron structure evolution as well...
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N6-methyladenosine writer METTL16-mediated alternative splicing and translation control are essential for murine spermatogenesis
BackgroundThe mitosis-to-meiosis switch during spermatogenesis requires dynamic changes in gene expression. However, the regulation of meiotic...
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Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
BackgroundAs the interest in manned spaceflight increases, so does the requirement to understand the transcriptomic mechanisms that underlay the...
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Exon-1 skipping and intron-1 retaining by alternative splicing of the c-KIT gene encodes a novel splice variant in the skin of Merino sheep (Ovis aries)
c -KIT , a type III receptor protein tyrosine kinase , plays an essential role in melanocyte development, migration, and survival. Mutations within the c
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Identification, Quantification, and Testing of Alternative Splicing Events from RNA-Seq Data Using SplAdder
Alternative splicing (AS) is a regulatory process during mRNA maturation that shapes higher eukaryotes’ complex transcriptomes. High-throughput...
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Alternative Splicing of Pre-messenger RNA
Alternative splicing is a critical component of gene expression. Virtually all multiexon genes undergo alternative splicing. By combining the...
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Alternative splicing analysis of lignocellulose-degrading enzyme genes and enzyme variants in Aspergillus niger
AbstractAlternative splicing (AS) greatly expands the protein diversity in eukaryotes. Although AS variants have been frequently reported existing in...
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A Method to Quantitatively Examine Heat Stress-Induced Alternative Splicing in Plants by RNA-Seq and RT-PCR
Alternative splicing (AS) of pre-mRNAs is a type of post-transcriptional regulation in eukaryotes that expands the number of mRNA isoforms. Intron...
