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Modeling cardiac microcirculation for the simulation of coronary flow and 3D myocardial perfusion
Accurate modeling of blood dynamics in the coronary microcirculation is a crucial step toward the clinical application of in silico methods for the...
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Tissue-growth-based synthetic tree generation and perfusion simulation
Biological tissues receive oxygen and nutrients from blood vessels by developing an indispensable supply and demand relationship with the blood...
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Development of a multiphase perfusion model for biomimetic reduced-order dense tumors
Dense fibrous extracellular constitution of solid tumors exerts high resistance to diffusive transport into it; additionally, the scarcity of blood...
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Development of a novel microfluidic perfusion 3D cell culture system for improved neuronal cell differentiation
Three-dimensional (3D) cell cultures have recently gained popularity in the biomedical sciences because of their similarity to the in vivo ...
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Experimental Investigation of Possibility of Simultaneously Monitoring Lung Perfusion/Cardiomotility and Ventilation via Thoracic Impedance Measurement
Impedance pneumography has a significant advantage for continuous and noninvasive monitoring of respiration, compared with conventional...
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A standard 96-well based high throughput microfluidic perfusion biofilm reactor for in situ optical analysis
Biofilm infections represent a major public health threat due to their high tolerance to antimicrobials and the lack of specific anti-biofilm drugs....
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Modeling and Simulation of Scaffolds in Varied Conditions Using CAD and Medical Images
When it comes to research methods, bone tissue engineering (BTE) has reached a certain level of maturity. As a result, modeling and simulation of BTE...
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Global Thermal Modeling of Lung Heat Transfer with Blood Perfusion
Thermal models often consider low-frequency approximations and are largely based upon RC circuits. If temperature fluctuations are non-negligible, a...
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A precision medicine framework for personalized simulation of hemodynamics in cerebrovascular disease
BackgroundCerebrovascular disease, in particular stroke, is a major public health challenge. An important biomarker is cerebral hemodynamics. To...
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Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
The use of porous 3D scaffolds for the repair of bone nonunion and osteoporotic bone is currently an area of great interest. Using a combination of...
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Dimensional synthesis of a novel 5-DOF reconfigurable hybrid perfusion manipulator for large-scale spherical honeycomb perfusion
A novel hybrid perfusion manipulator (HPM) with five degrees of freedom (DOFs) is introduced by combining the 5PUS-PRPU (P, R, U, and S represent...
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Cardiac flow velocity measurement with magnetic resonance for simulation by finite volumes
This study aims to analyze methods that facilitate the measurement and acquisition of flow velocities in the great thoracic vessels using a...
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Simulation of avascular tumor growth and drug response in a microfluidic device with a cellular automaton model
The microfluidic system is capable of recapitulating key attributes of in vivo circumstances and, therefore, becomes a valuable platform for better...
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Computer Simulation of the Effects of Water Bolus Parameters on the Specific Absorption Rate and Temperature Distribution for the Treatment of Abdominal Tumor
AbstractIn this paper, the effect of water bolus coupling layer on the hyperthermia assurance parameters i.e. specific absorption rate (SAR) and...
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Numerical study on the effects of blood perfusion and tumor metabolism on tumor temperature for targeted hyperthermia considering a realistic geometrical model of head layers using the finite element method
The main aim of the present work is to determine the temperature distribution in the normal and cancerous tissues to achieve the desired condition of...
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Patient-specific simulation of high-intensity focused ultrasound for head and neck cancer ablation
This study used acoustic and biothermal simulations on reconstructed geometry of a patient with squamous cell carcinoma to investigate the...
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Simulation-Based Treatment Protocol Design for Damaging Breast Tumor Using Laser Photothermal Therapy
Laser photothermal therapy utilizes gold nanorods/nanoshells embedded in tumors to enhance laser energy absorption in tumors via minimizing laser...
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Transient changes during microwave ablation simulation : a comparative shape analysis
Microwave ablation therapy is a hyperthermic treatment for killing cancerous tumours whereby microwave energy is dispersed into a target tissue...
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Fluid–structure interaction (FSI) simulation for studying the impact of atherosclerosis on hemodynamics, arterial tissue remodeling, and initiation risk of intracranial aneurysms
The biomechanical and hemodynamic effects of atherosclerosis on the initiation of intracranial aneurysms (IA) are not yet clearly discovered. Also,...
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Mathematical modeling and numerical simulation of arterial dissection based on a novel surgeon’s view
This paper presents a mathematical model for arterial dissection based on a novel hypothesis proposed by a surgeon, Axel Haverich, see Haverich...
