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Mechanical Stimuli for Left Ventricular Growth During Pressure Overload
BackgroundThe mechanical stimulus (i.e., stress or stretch) for growth occurring in the pressure-overloaded left ventricle (LV) is not exactly known.
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Simulating impaired left ventricular–arterial coupling in aging and disease: a systematic review
Aortic stenosis, hypertension, and left ventricular hypertrophy often coexist in the elderly, causing a detrimental mismatch in coupling between the...
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Predictions of hypertrophy and its regression in response to pressure overload
Mechanics-based cardiac growth models can now predict changes in mass, chamber size, and wall thickness in response to perturbations such as pressure...
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A homogenized constrained mixture model of cardiac growth and remodeling: analyzing mechanobiological stability and reversal
Cardiac growth and remodeling (G&R) patterns change ventricular size, shape, and function both globally and locally. Biomechanical, neurohormonal,...
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Mechano-regulated cell–cell signaling in the context of cardiovascular tissue engineering
Cardiovascular tissue engineering (CVTE) aims to create living tissues, with the ability to grow and remodel, as replacements for diseased blood...
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Left Ventricular Geometry, Tissue Composition, and Residual Stress in High Fat Diet Dahl-Salt Sensitive Rats
BackgroundHypertension drives myocardial remodeling, leading to changes in structure, composition and mechanical behavior, including residual stress,...
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Inhibition of BRD4 inhibits proliferation and promotes apoptosis of psoriatic keratinocytes
BackgroundPsoriasis is a common chronic recurrent inflammatory skin disease. The pathogenesis of psoriasis, such as other autoimmune diseases, is...
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Clinical Applications of Polarization-Sensitive Optical Coherence Tomography
Polarization-sensitive optical coherence tomography (PS-OCT) measures the polarization state in addition to the pathlength and amplitude of light...
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Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome
Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome...
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Patient-Specific Multi-Scale Model Analysis of Hemodynamics Following the Hybrid Norwood Procedure for Hypoplastic Left Heart Syndrome: Effects of Reverse Blalock–Taussig Shunt Diameter
IntroductionThe hybrid Norwood (HN) is a relatively new first stage palliative procedure for neonates with hypoplastic left heart syndrome, in which...
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Collagen Self-assembly: Biophysics and Biosignaling for Advanced Tissue Generation
Type I collagenCollagen is the predominant protein in the body and the extracellular matrixExtracellular matrix, where it gives rise to the vast...
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Arterial Wall Stiffening in Caveolin-1 Deficiency-Induced Pulmonary Artery Hypertension in Mice
BackgroundPulmonary artery hypertension (PAH) is a complex disorder that can lead to right heart failure. The generation of caveolin-1 deficient mice...
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Microstructural characterization of annulus fibrosus by ultrasonography: a feasibility study with an in vivo and in vitro approach
The main function of the intervertebral disc is biomechanical function, since it must resist repetitive high loadings, while giving the spine its...
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Novel Views on Heart Function from Dynamic Hyperpolarized NMR
The heart beats constantly and requires continuous production of adenosine triphosphate (ATP) to power contraction. ATP is generated predominantly in...
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Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences
Aging leads to central artery stiffening and associated hemodynamic sequelae. Because healthy arteries exhibit differential geometry, composition,...
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Structural Building Blocks of Soft Tissues: Tendons and Heart Valves
Modelling the mechanical behaviour of soft tissues like tendon, ligament, skin and cartilage requires a knowledge of the structural and mechanical...
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Comparison of Blood Viscoelasticity in Pediatric and Adult Cardiac Patients
Evidence is accumulating that blood flow patterns in the cardiovascular system and in cardiovascular devices do, in some instances, depend on blood...
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Imaging in Vascular Access
This review examines four imaging modalities; ultrasound (US), digital subtraction angiography (DSA), magnetic resonance imaging (MRI) and computed...
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Fault Diagnosis in Highly Dependable Medical Wearable Systems
High levels of dependability are required to promote the adherence by public and medical communities to wearable medical devices. The study presented...
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4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics
Blood flow plays a critical role in regulating embryonic cardiac growth and development, with altered flow leading to congenital heart disease....
