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Efficient virtual high-content screening using a distance-aware transformer model
Molecular similarity search is an often-used method in drug discovery, especially in virtual screening studies. While simple one- or two-dimensional...
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Metabolic analysis of Schizochytrium sp. mutants with high EPA content achieved with ARTP mutagenesis screening
Eicosapentaenoic acid (EPA) belonged to the ω-3 series of polyunsaturated fatty acids and had physiological functions lipid as regulating blood lipid...
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Effective synthesis of high-content fructooligosaccharides in engineered Aspergillus niger
BackgroundAspergillus niger ATCC 20611 is an industrially important fructooligosaccharides (FOS) producer since it produces the β-fructofuranosidase...
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Screening for New Metabolites from Marine Microorganisms
This article gives an overview of current analysis techniques for the screening and the activity analysis of metabolites from marine...
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Screening Methods for Biosurfactant-Producing Microorganisms
Biosurfactants are attractive amphiphilic surface-active molecules. They reduce the surface tension and have emulsification, foam formation,...
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Fungal Biodegradation of a Hybrid Adhesive Polymer Containing High-Biomass Content
Water-based acrylic pressure-sensitive adhesives (PSA) are a common component of disposable products such as tapes, labels, and packaging. Such...
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Molecular Docking for Virtual Screening of Potential Active Ingredients in Chinese Medicines
Traditional Chinese medicine (TCM) plays a vital role in the prevention and treatment of various diseases for thousands of years. It is of great...
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Droplet microarray platforms for high-throughput drug screening
AbstractHigh-throughput screening platforms are fundamental for the rapid and efficient processing of large amounts of experimental data....
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Novel evolved Yarrowia lipolytica strains for enhanced growth and lipid content under high concentrations of crude glycerol
BackgroundYarrowia lipolytica is a well-studied oleaginous yeast known for its ability to accumulate and store intracellular lipids, while growing...
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High-Throughput Screening to Accelerate Microalgae-Based Phycochemical Production
Microalgae biotechnologies tap into the huge energy resource of the sun, absorb CO2, and are being developed to provide economic solar-driven...
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Traditional Screening and Genome-Guided Screening of Natural Products from Actinobacteria
Since the golden era of antibiotics, around one half of the antibiotics that are available in the market were discovered. From 1960, a drop in the...
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Chromatographic Separation with On-Line (Bio)Assay, a Rapid Technique for Screening Active Compounds from Chinese Medicines
Due to the complex compositions of Chinese medicine (CM), how to rapidly and efficiently discovery the biologically active components from them is a...
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Screening of neoteric solvents for gossypol extraction from cottonseed oil
Gossypol, a yellow-coloured matter, is originated from cotyledon during the germination stage of the seed of the cotton plant. Due to its various...
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Extraction of Nitrate from Grapevine Petiole and its Determination by Using UV-Spectrometric Screening Method: a Comparative Study
AbstractEstimation of nitrate accumulation in grapevine plant tissue has a great significance in grape production. In this method, nitrate was...
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A Rapid Single Kernel Screening Method for Preliminary Estimation of Amylose in Maize
The development of low glycaemic index maize varieties requires screening of a large number of inbreds in shortest time. Conventional amylose...
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Development of a yeast cell based method for efficient screening of high yield tacrolimus production strain
Tacrolimus (FK506) is a widely used and clinically important immunosuppressant drug that can be produced by fermentation of Streptomyces tsukubaensis ....
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Rapid Screening of Industrial Hemp Based on Handheld Near Infrared Spectrometer
To realize the rapid screening of industrial hemp for procurement, a method for evaluating the content of total cannabidiol (CBD) and total...
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Phytochemical Screening and Chemical Characterization of the Bioactive Metabolites
Preliminary phytochemical analysis of the crude extract is carried out for the detection of primary as well as secondary metabolites present in the...
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes
Drug discovery relies on efficient identification of small-molecule leads and their interactions with macromolecular targets. However, understanding...
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Accelerated discovery of molecular nanojunction photocatalysts for hydrogen evolution by using automated screening and flow synthesis
Discovering and optimizing multicomponent organic semiconductors is typically a laborious process. High-throughput experimentation can accelerate...
