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Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease
BackgroundNovel phosphorylated-tau (p-tau) blood biomarkers (e.g., p-tau181, p-tau217 or p-tau231), are highly specific for Alzheimer’s disease (AD),...
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Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice
Tau oligomers play critical roles in tau pathology and are responsible for neuronal cell death and transmitting the disease in the brain....
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Torpor induces reversible tau hyperphosphorylation and accumulation in mice expressing human tau
Tau protein hyperphosphorylation and aggregation are key pathological events in neurodegenerative tauopathies such as Alzheimer’s disease....
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Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials...
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Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous...
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Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice
Accumulation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau is a histopathological hallmark of Alzheimer’s disease (AD) and...
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FGFR3 drives Aβ-induced tau uptake
The amyloid cascade hypothesis suggests that amyloid beta (Aβ) contributes to initiating subsequent tau pathology in Alzheimer’s disease (AD)....
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Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau...
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Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer’s Disease–Related Epitopes and Increases Intraneuronal Tau Levels
Metabolic diseases derived from an unhealthy lifestyle have been linked with an increased risk for developing cognitive impairment and even...
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Toxic Tau Aggregation in AD
Alzheimer’s disease (AD) is a neurodegenerative disorder that is caused by multiple factors, has a complicated physiopathology, and the causes of its...
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Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Tauopathies are neurodegenerative diseases that typically require postmortem examination for a definitive diagnosis. Detecting neurotoxic tau...
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Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease
BackgroundTo better assist with the design of future clinical trials for Alzheimer’s disease (AD) and aid in our understanding of the disease’s...
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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis
Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer’s disease, microglia get activated to...
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Cerebrospinal fluid alpha-synuclein, amyloid beta, total tau, and phosphorylated tau in tremor-dominant Parkinson’s disease
BackgroundProtein misfolding within specific brain regions is a common characteristic of neurodegenerative diseases, such as Alzheimer's disease and...
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A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies,...
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Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration
Abnormal posttranslational modifications of tau play important roles in mediating neurodegeneration in tauopathies including Alzheimer’s disease....
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Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
Most neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a...
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Reinstated Activity of Human Tau-induced Enhanced Insulin Signaling Restricts Disease Pathogenesis by Regulating the Functioning of Kinases/Phosphatases and Tau Hyperphosphorylation in Drosophila
Tauopathies such as Alzheimer’s disease (AD), Frontotemporal dementia, and parkinsonism linked to chromosome 17 (FTDP-17), etc. are characterized by...
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Nuclear face of Tau: an inside player in neurodegeneration
Tau (Tubulin associated unit) protein is a major hallmark of Alzheimer’s disease (AD) and tauopathies. Tau is predominantly an axonal protein with a...
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Aβ and Tau Prions Causing Alzheimer’s Disease
Studies show that patients with Alzheimer’s disease (AD) have both Aβ and tau prions, and thus, AD is a double-prion disease. AD patients with the...
