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Canagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation
Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to...
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Bioinformatical View on the Contribution of MAST/IRE-Dependent Phosphorylation in the Tubulin Code
AbstractProtein kinases represent one of the largest eukaryotic enzyme superfamilies. However, only a few can directly phosphorylate tubulin and...
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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated...
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Corydaline alleviates Parkinson’s disease by regulating autophagy and GSK-3β phosphorylation
BackgroundJitai tablet, a traditional Chinese medicine, has a neuroprotective effect on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine...
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Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats
ObjectiveAnesthetics have been linked to cognitive alterations, particularly in the elderly. The current research delineates how Fibroblast Growth...
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Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression
ObjectiveThis study aims to elucidate the functional role of IQGAP1 phosphorylation modification mediated by the SOX4/MAPK1 regulatory axis in...
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Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells
Tau is a microtubule-associated protein that is regulated by post-translational modifications. The most studied of these modifications is...
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Eucalyptol induces osteoblast differentiation through ERK phosphorylation in vitro and in vivo
AbstractEucalyptol (EU) is monoterpene oxide that is the main component of the essential oil extracted from aromatic plants such as Eucalyptus...
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Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer
Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations....
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Phosphorylation of AQP4 by LRRK2 R1441G impairs glymphatic clearance of IFNγ and aggravates dopaminergic neurodegeneration
Aquaporin-4 (AQP4) is essential for normal functioning of the brain’s glymphatic system. Impaired glymphatic function is associated with...
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Regulation of Par-4 Function by Phosphorylation
This chapter discusses the regulatory role of the phosphorylation of the tumor suppressor protein, Par-4 (PAWR, PRKC, apoptosis Wilm’s tumor 1...
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Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury
AbstractLiver injury is closely associated with macrophage activation following HBV infection. Our previous study showed that only HBeAg, but not...
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KPNA2 promotes angiogenesis by regulating STAT3 phosphorylation
PurposeAngiogenesis is involved in many pathological and physiological processes and is mainly driven by hypoxia. Karyopherin subunit alpha 2...
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Runx1 Deficiency Promotes M2 Macrophage Polarization Through Enhancing STAT6 Phosphorylation
Our previous study had demonstrated that Runx1 promoted LPS-induced macrophage inflammatory response, however, the role of Runx1 in M2 macrophage...
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TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
PurposeTIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatases PP2A, PP4 and PP6...
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BDNF alleviates Parkinson's disease by promoting STAT3 phosphorylation and regulating neuronal autophagy
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual death of dopaminergic neurons. Brain-derived neurotrophic...
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Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses
The neurotoxicity of Semen Strychni has been reported recently in several clinical cases. Therefore, this study was conducted to investigate the role...
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FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2
The forkhead box O1 (FOXO1) is an important transcription factor related to proliferation, metabolism, and homeostasis, while the major phenotype of...
