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Experimental Medicine Approaches in Early-Phase CNS Drug Development
Traditionally, Phase 1 clinical trials were largely conducted in healthy normal volunteers and focused on collection of safety, tolerability, and...
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The Role of fMRI in Drug Development: An Update
Functional magnetic resonance imaging (fMRI) of the brain is a technology that holds great potential for increasing the efficiency of drug...
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Cannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice
BackgroundThe phytocannabinoid cannabidiol (CBD) exhibits anxiolytic activity and has been promoted as a potential treatment for post-traumatic...
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Conventional Behavioral Models and Readouts in Drug Discovery: The Importance of Improving Translation
This chapter describes the relevance and importance of preclinical models and readouts in the drug development process. Recently, animal behavioral...
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MRI in CNS Drug Development
There are three ways in which magnetic resonance imaging is typically used in drug development: to validate the role of drugs and...
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Fentanyl-induced changes in brain activity in awake nonhuman primates at 9.4 Tesla
Functional magnetic resonance imaging (fMRI) has been used to study the influence of opioids on neural circuitry implicated in opioid use disorder,...
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Noninvasive Methodology (NMR)
Neuroimaging with MRI provides a noninvasive means to assess drug effects in vivo. In addition to the discovery of potential markers of...
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The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders
Historically, animal models have been routinely used in the characterization of novel chemical entities (NCEs) for various psychiatric disorders....
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Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects
BackgroundAberrant glutamate neurotransmission, and in particular dysfunction of the N -methyl- d -aspartate receptor (NMDAR), has been implicated in...
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Imaging Kappa Opioid Receptors in the Living Brain with Positron Emission Tomography
Kappa opioid receptor (KOR) neuroimaging using positron emission tomography (PET) has been immensely successful in all phases of discovery and...
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Current Glutamatergic Treatments and Future Directions for Glutamate-Based Management of Chronic Stress and Stress-Related Disorders
The recent Food and Drug Administration and European Medicine Agency regulatory approval of intranasal (S)-Ketamine for the treatment-resistant...
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Noninvasive Methodology (NMR)
Neuroimaging with MRI provides a noninvasive means to assess drug effects in vivo. In addition to the discovery of potential markers of...
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Neuropsychopharmacology: Recent MEG Investigations
Neuroimaging methods can play an increasingly important role in a highly complex drug development process by providing sensitive biomarkers of...
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Long-term effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attention-deficit hyperactivity disorder
Stimulant prescription rates for attention deficit hyperactivity disorder (ADHD) are increasing, even though potential long-term effects on the...
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Opioid receptors: drivers to addiction?
Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain...
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Pharmacodynamic Evaluation: Pain Methodologies
Despite many advances in the last decades in understanding pain, the development of new analgesic compounds has not followed the same pace. The...
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Pharmaco-Based fMRI and Neurophysiology in Non-Human Primates
Brain activity is continuously changing, among others reflecting the effects of neuromodulation on multiple spatial and temporal scales. By altering...
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Effects of the Serotonin 5-HT1A Receptor Biased Agonists, F13714 and F15599, on Striatal Neurotransmitter Levels Following l-DOPA Administration in Hemi-Parkinsonian Rats
Peak-dose dyskinesia is associated with the dramatic increase in striatal dopamine levels that follows l -DOPA administration. The ‘false...
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Ketamine-induced changes in connectivity of functional brain networks in awake female nonhuman primates: a translational functional imaging model
RationaleThere is a significant interest in the NMDA-receptor antagonist ketamine due to its efficacy in treating depressive disorders and its...
