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Reconstitution of Neuronal Motor Traffic on Septin-Associated Microtubules
Reconstitution of intracellular transport in cell-free in vitro assays enables the understanding and dissection of the molecular mechanisms that...
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Characterization of human Ccser2 as a protein tracking the plus-ends of microtubules
ObjectiveMicrotubules, which are closely related to cell proliferation, have been the promising therapeutic target of cancer. Therefore, it is...
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Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress
Variations in the gene encoding filamin-A-interacting protein 1 ( FILIP1 ) were identified to be associated with a combination of neurological and...
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The Role of Posttranslational Acetylation in the Association of Autophagy Protein ATG8 with Microtubules in Plant Cells
AbstractOur study was aimed to anlayze the mechanism of the effect of acetylation of the Lys40 residue in α-tubulin TUBA4 from A. thaliana on its...
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Imaging Microtubule Network in Rodent Giant Glutamatergic Presynaptic Terminals
Increasing interest and evidence have pointed to the critical role of cytoskeleton elements such as microtubules or actin filaments in the regulation...
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Plant and mouse EB1 proteins have opposite intrinsic properties on the dynamic instability of microtubules
ObjectiveMost eukaryotic cells contain microtubule filaments, which play central roles in intra-cellular organization. However, microtubule networks...
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Doublecortin-like kinase is required for cnidocyte development in Nematostella vectensis
The complex morphology of neurons requires precise control of their microtubule cytoskeleton. This is achieved by microtubule-associated proteins...
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Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270
Gephyrin is a multifunctional scaffolding protein anchoring glycine- and subtypes of GABA type A- receptors at inhibitory postsynaptic membrane...
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Coronavirus and the Cytoskeleton of Virus-Infected Cells
The cytoskeleton, which includes actin filaments, microtubules, and intermediate filaments, is one of the most important networks in the cell and...
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Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD
The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a major pathological hallmark of amyotrophic lateral sclerosis...
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Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions
Alzheimer’s disease (AD), a multifactorial disease, is characterized by the accumulation of neurofibrillary tangles (NFTs) and amyloid beta (Aβ)...
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Insights on the Role of α- and β-Tubulin Isotypes in Early Brain Development
Tubulins are the highly conserved subunit of microtubules which involve in various fundamental functions including brain development. Microtubules...
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Centrosome, microtubule and DNA damage response
Centrosomes are the major microtubule-organizing center (MTOC), which are important cytoplasmic organelles regulating cell cycle, cell morphology,...
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Studying the Role of Protein Kinases CK1 in Organization of Cortical Microtubules in Arabidopsis thaliana Root Cells
AbstractThe members of the casein kinase 1 (CK1) subfamily are distinguished by interspecific conservatism and an extensive set of phosphorylation...
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Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction
BackgroundThe leading cause of cancer-related mortality worldwide is lung cancer, and its clinical outcome and prognosis are still unsatisfactory....
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β-Tubulin of Fusarium as a Potential Target for Realization of Antifungal Activity of Ivermectin
The analysis of the effect of ivermectin on phytopathogenic strains of Fusarium graminearum (F‑55644, F-55748) and Fusarium oxysporum f. sp. lycopersici...
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Structural Biological Characteristics of CK1-Like Protein Kinase Isotypes Associated with Regulation of Plant Microtubules
AbstractEighteen isotypes of CK1-like protein kinases were identified in A. thaliana . Comparison of catalytic domains in rat CK1 (α, β, γ1–3, δ, and...
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Nanoarchitecture of the ventral disc of Giardia intestinalis as revealed by high-resolution scanning electron microscopy and helium ion microscopy
The parasitic protozoan Giardia intestinalis , the causative agent of giardiasis, presents a stable and elaborated cytoskeleton, which shapes and...
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Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
In Alzheimer disease (AD), Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and...
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Advances in Understanding the Molecular Mechanisms of Neuronal Polarity
The establishment and maintenance of neuronal polarity are important for neural development and function. Abnormal neuronal polarity establishment...
