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1. LncRNA BBOX1-AS1 Contributes to Laryngeal Carcinoma Progression by Recruiting SRSF1 to Maintain EFNB2 mRNA Stability

   Laryngeal cancer is a common malignancy of the larynx with a generally poor prognosis. This study systematically assessed the functional role of...

   Xiaowen Zhu, Xuan Li, ... Jian Ni in Biochemical Genetics

   Article 04 July 2024
   

2. Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability

   During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines....

   Lizhou Zhang, Kunal R. More, ... Hyeryun Choe in npj Vaccines

   Article Open access 11 October 2023
   

3. UTP11 promotes the growth of hepatocellular carcinoma by enhancing the mRNA stability of Oct4

   Background

   Several publications suggest that UTP11 may be a promising gene engaged for involvement of hepatocellular carcinoma (HCC) pathology....

   Yan Chen, Xiaowei Zhang, ... Guodong Li in BMC Cancer

   Article Open access 17 January 2024
   

4. IGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1

   Background

   Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) has been implicated in numerous inflammatory and cancerous conditions....

   Honglin Wang, Yingying Cao, ... Zongfeng Zhang in Molecular Medicine

   Article Open access 17 May 2024
   

5. mRNA Vaccines

   The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the...

   Dong Yu, Benjamin Petsch in Current Topics in Microbiology and Immunology

   Book 2022
   

6. P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC

   Background

   N7-methylguanosine (m7G) modification is, a more common epigenetic modification in addition to m6A modification, mainly found in mRNA...

   Mingpeng Zhang, Duo Kan, ... Zhiqun Shang in Journal of Experimental & Clinical Cancer Research

   Article Open access 21 August 2023
   

7. Oligonucleotides and mRNA Therapeutics

   Two important classes of therapeutics based on nucleic acids are synthetic oligonucleotides and mRNA generated by in vitro transcription (IVT)....

   Erik Oude Blenke, Raymond M. Schiffelers, Enrico Mastrobattista in Pharmaceutical Biotechnology

   Chapter 2024
   

8. mRNA-Based Cancer Therapy and Challenges

   Messenger ribonucleic acid (mRNA), an emerging class of novel nucleic acid therapeutics, is a type of single-stranded RNA using the DNA strand as a...

   Xin Xin, Wei Huang in Handbook of Cancer and Immunology

   Living reference work entry 2023
   

9. GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability

   Pancreatic ductal adenocarcinoma (PDAC) is characterized by a hypoxic microenvironment, a high rate of heterogeneity as well as a high likelihood of...

   Yunhui Zhou, Xinyi Zhou, ... Lin Zhou in Journal of Translational Medicine

   Article Open access 06 December 2023
   

10. Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m⁶A-modified PTEN mRNA in pancreatic ductal adenocarcinoma

    The role of circular RNAs (circRNAs) in glucose metabolism in pancreatic duct adenocarcinoma (PDAC) remains elusive. Through RNA sequencing of cells...

    Dandan Zheng, Wenying Chen, ... Yanyan Zhuang in Cancer Gene Therapy

    Article 27 May 2024
    

11. CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability

    Background

    Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA binding protein with multiple roles in regulation of gene...

    Feifei Yang, Qiang Ma, ... Bin Xiao in Journal of Translational Medicine

    Article Open access 20 June 2023
    

12. Circ_0002331 Interacts with ELAVL1 to Improve ox-LDL-Induced Vascular Endothelial Cell Dysfunction via Regulating CCND2 mRNA Stability

    Circular RNAs (circRNAs) have been discovered to serve as vital regulators in atherosclerosis (AS). However, the role and mechanism of circ_0002331...

    Feng Chen, Xiufeng Yu in Cardiovascular Toxicology

    Article 14 May 2024
    

13. Solutions for mRNA Optimization

    It took a lot of hard work before a synthetic mRNA could be administered to humans to protect them from or treat viral infections or cancers. With...

    Jérôme Lemonnier, Nicolas Lemonnier in The Marathon of the Messenger

    Chapter 2023
    

14. Long non-coding RNA SNHG4 enhances RNF14 mRNA stability to promote the progression of colorectal cancer by recruiting TAF15 protein

    SNHG4 is a lncRNA that was previously reported to promote colorectal cancer (CRC) progression via molecular sponge mechanism. Bioinformatic analysis...

    Lv Lv, Bojie Huang, ... Li Zhang in Apoptosis

    Article 09 December 2022
    

15. Exosomal Linc00969 induces trastuzumab resistance in breast cancer by increasing HER-2 protein expression and mRNA stability by binding to HUR

    Background

    Breast cancer (BC) is the most common malignant disease in female patients worldwide. In HER-2+ BC patients, trastuzumab therapy is...

    Cuiwei Liu, Chong Lu, ... Xiangwang Zhao in Breast Cancer Research

    Article Open access 17 October 2023
    

16. TGF-β-activated circRYK drives glioblastoma progression by increasing VLDLR mRNA expression and stability in a ceRNA- and RBP-dependent manner

    Background

    The TGF-β signalling pathway is intricately associated with the progression of glioblastoma (GBM). The objective of this study was to...

    Yuhang Wang, Binbin Wang, ... Xiupeng Xu in Journal of Experimental & Clinical Cancer Research

    Article Open access 08 March 2024
    

17. ALKBH5-mediated m⁶A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability

    Background

    Impaired wound re-epithelialization contributes to cutaneous barrier reconstruction dysfunction. Recently, N ⁶ -methyladenosine (m ⁶ A) RNA...

    Xin Huang, Yixuan Zhao, ... Tao Zan in Inflammation and Regeneration

    Article Open access 14 July 2023
    

18. Tailor made: the art of therapeutic mRNA design

    mRNA medicine is a new and rapidly developing field in which the delivery of genetic information in the form of mRNA is used to direct therapeutic...

    Mihir Metkar, Christopher S. Pepin, Melissa J. Moore in Nature Reviews Drug Discovery

    Article 29 November 2023
    

19. NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m⁵C methylation

    Background

    RNA m ⁵ C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2...

    Xuran Zhang, Ke An, ... Xin Tian in Breast Cancer Research

    Article Open access 06 June 2024
    

20. YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma

    YAP is a transcriptional co-activator with critical roles in tumorigenesis. However, its upstream regulatory mechanism, especially how its mRNA...

    Wenjun Yu, Congcong Zhang, ... Jinjing Xia in Cancer Gene Therapy

    Article Open access 19 September 2022