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Trypanosoma brucei brucei Induced Hypoglycaemia Depletes Hepatic Glycogen and Altered Hepatic Hexokinase and Glucokinase Activities in Infected Mice
PurposeLittle progress has been made in understanding the effect of Trypanosoma brucei brucei infection that was allowed to run its course without...
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Investigation of phytoconstituents of Enicostemma littorale as potential glucokinase activators through molecular docking for the treatment of type 2 diabetes mellitus
Glucokinase (GK) is an enzyme involved in synthesising glucose into glucose-6 phosphate and serves a crucial function in glucose sensing. Therefore,...
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Design and synthesis of newer N-benzimidazol-2yl benzamide analogues as allosteric activators of human glucokinase
Allosteric activators of human glucokinase (GK) had revealed significant hypoglycemic effects for therapy of type-2 diabetes (T2D) in animal as well...
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Involvement of Nitric Oxide in Insulin Secretion to Carbohydrate Metabolism
Since the discovery of nitric oxide (NO) as an important mediator of vasoregulation, the molecule has been found to be involved in several...
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Dorzagliatin in drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial
Improving glucose sensitivity remains an unmet medical need in treating type 2 diabetes (T2D). Dorzagliatin is a dual-acting, orally bioavailable...
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Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma glucose levels....
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Antidiabetic potential of Chromolaena Odorata leave extract and its effect on Nrf2/keap1 antioxidant pathway in the liver of diabetic-induced Wistar Rats
The incidence of liver dysfunction increases in diabetes due to insulin resistance and oxidative stress. Chromolaena odorata is a dominant medicinal...
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Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice
Several humoral factors, such as adiponectin and urate, have been suggested to affect metabolic syndromes. Previously, we reported a reduction in...
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Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease
ObjectiveGCK rs780094 polymorphism is a single nucleotide polymorphism that has been associated with obesity, type II diabetes and dyslipidemia in...
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FiTMuSiC: leveraging structural and (co)evolutionary data for protein fitness prediction
Systematically predicting the effects of mutations on protein fitness is essential for the understanding of genetic diseases. Indeed, predictions...
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Sex Dimorphic Glucose Transporter-2 Regulation of Hypothalamic Astrocyte Glucose and Energy Sensor Expression and Glycogen Metabolism
The plasma membrane glucose transporter-2 (GLUT2) monitors brain cell uptake of the critical nutrient glucose, and functions within astrocytes of...
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Interplay of Mediterranean-diet adherence, genetic factors, and metabolic dysfunction-associated steatotic liver disease risk in Korea
BackgroundsMetabolic dysfunction-associated steatotic liver disease (MASLD) has gained attention owing to its severe complications. This study aimed...
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Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is common and partially heritable and has no effective treatments. We carried out a genome-wide association...
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Anti-diabetes Research in India: Contributions from Industrial Organizations
The various aspects of past, present, and future of anti-diabetes research in India are covered here. A brief introduction on prevalence of diabetes...
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Genetic testing of GCK-MODY identifies a novel pathogenic variant in a Chinese boy with early onset hyperglycemia
Glucokinase-maturity-onset diabetes of the young (GCK-MODY or MODY 2), caused by a heterozygous inactivating variant in the Glucokinase ( GCK) gene,...
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A structural model of glucose regulation for building prognostic algorithms for controlling insulin therapy
This work discusses the physiological processes influencing the dynamics of blood glucose concentration in patients with diabetes mellitus and...
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Linking Variants of Hemoglobin A1C and Glycemic Status
Hemoglobin A1C (HbA1c) has been used as a convenient screening test for the diagnosis of diabetes and prediabetes, requiring no fasting, as well as a...
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The emergence of sulfo-click amidation in kinetic target-guided synthesis
Sulfo-click is a chemoselective and biocompatible reaction between thioacids and sulfonyl azides that forms highly versatile N -acylsulfonamides,...
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Genome Editing and Fatty Liver
Fatty liver disease is characterized as nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Fatty liver disease is one of the...
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Interaction between the GCKR rs1260326 variant and serum HDL cholesterol contributes to HOMA-β and ISIMatusda in the middle-aged T2D individuals
This study aims to investigate the correlations between islet function/ insulin resistance and serum lipid levels, as well as to assess whether the...
