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Identification of Germline Mutations in East-Asian Young Never-Smokers with Lung Adenocarcinoma by Whole-Exome Sequencing
Recently, an increasing number of young never-smokers are diagnosed with lung cancer. The aim of this study is to investigate the genetic...
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Accelerated epigenetic age, inflammation, and gene expression in lung: comparisons of smokers and vapers with non-smokers
BackgroundCigarette smoking and aging are the main risk factors for pulmonary diseases, including cancer. Epigenetic aging may explain the...
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Multimodal 7T imaging reveals enhanced functional coupling between salience and frontoparietal networks in young adult tobacco cigarette smokers
Tobacco cigarette smoking is associated with disrupted brain network dynamics in resting brain networks including the Salience (SN) and Fronto...
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Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults
BackgroundCOPD is associated with an abnormal lung immune response that leads to tissue damage and remodeling of the lung, but also to systemic...
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Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers
RationaleReducing nicotine content in cigarettes to ≤ 2.4 mg per g of tobacco [mg/g] reduces smoking behavior and toxicant exposure among adult daily...
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Ectodomain shedding of proteins important for SARS-CoV-2 pathogenesis in plasma of tobacco cigarette smokers compared to electronic cigarette vapers: a cross-sectional study
The impact of tobacco cigarette (TCIG) smoking and electronic cigarette (ECIG) vaping on the risk of development of severe COVID-19 is controversial....
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Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
RationaleReducing nicotine content of inhaled tobacco products may prevent nicotine addiction, but the threshold for nicotine reinforcement has not...
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A novel prognostic signature based on smoking-associated genes for predicting prognosis and immune microenvironment in NSCLC smokers
BackgroundAs a highly heterogeneous tumor, non-small cell lung cancer (NSCLC) is famous for its high incidence and mortality worldwide. Smoking can...
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Assessment of brain connectome alterations in male chronic smokers using structural and generalized q-sampling MRI
An association has been shown between chronic cigarette smoking and structural abnormalities in the brain areas related to several functions relevant...
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Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers
BackgroundTobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of...
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The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates
Nicotine and tobacco product (NTP) use remains prevalent in adolescence/young adulthood. The effects of NTPs on markers of brain health during this...
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The changes of brain functional networks in young adult smokers based on independent component analysis
Intrinsic functional connectivity (FC) networks, including the default mode network (DMN), central executive network (CEN), and salience network...
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Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers
BackgroundThe incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily increasing among non-smokers. Previous research has identified...
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Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals
The purpose of this study was to clarify sex differences in the inhibition of sympathetic vasomotor outflow which is caused by the loading of...
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Association between depression and young-onset dementia in middle-aged women
BackgroundDementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (YOD), when...
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Cigarette-specific disgust aroused by smoking warning images strengthens smokers’ inhibitory control under smoking-related background in Go/NoGo task
RationaleReduced inhibitory control is more pronounced during substance-related cue exposure among addicts. However, it is inconclusive whether...
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Untargeted serum metabolomic profiles and breast density in young women
Purpose of the studyBreast density is an established risk factor for breast cancer. However, little is known about metabolic influences on breast...
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Association between functional brain alterations and neuropsychological scales in male chronic smokers using resting-state fMRI
RationaleRecent studies have demonstrated that cigarette smoking is related to changes in brain structure and function. However, few studies focus on...
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Childhood adiposity, serum metabolites and breast density in young women
BackgroundChildhood adiposity is inversely associated with young adult percent dense breast volume (%DBV) and absolute dense breast volume (ADBV),...
