Search
Search Results
-
Targeting vimentin: a multifaceted approach to combatting cancer metastasis and drug resistance
This comprehensive review explores vimentin as a pivotal therapeutic target in cancer treatment, with a primary focus on mitigating metastasis and...
-
LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer
BackgroundLadinin-1 (LAD1), an anchoring filament protein, has been associated with several cancer types, including cancers of the colon, lungs, and...
-
LINC01559 promotes lung adenocarcinoma metastasis by disrupting the ubiquitination of vimentin
BackgroundDistant metastasis is the major cause of lung adenocarcinoma (LUAD)-associated mortality. However, molecular mechanisms involved in LUAD...
-
Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells
BackgroundPolyploid giant cancer cells (PGCCs), a specific type of cancer stem cells (CSCs), can be induced by hypoxic microenvironments, chemical...
-
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation
BackgroundCircular RNAs (circRNAs) have been proved to play crucial roles in the development of various cancers. However, the molecular mechanism of...
-
The E3 ligase NEURL3 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma by promoting vimentin degradation
BackgroundMetastasis has emerged as the major reason of treatment failure and mortality in patients with nasopharyngeal carcinoma (NPC). Growing...
-
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression
BackgroundInvasion and metastasis are the main causes of unfavourable prognosis in patients diagnosed with bladder cancer. The efficacy of...
-
Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions
Wound healing depends largely on the remodeling of the extracellular matrix around and reorganization of tissue-resident cells. Matrix remodeling...
-
Exploring new frontiers: cell surface vimentin as an emerging marker for circulating tumor cells and a promising therapeutic target in advanced gastric Cancer
BackgroundCirculating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their...
-
A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity
BackgroundOsteosarcoma (OS) is one of most commonly diagnosed bone cancer. Circular RNAs (circRNAs) are a class of highly stable non-coding RNA, the...
-
A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer
RAS oncogenes are major drivers of diverse types of cancer. However, they are largely not druggable, and therefore targeting critical downstream...
-
Effects of host vimentin on Eimeria tenella sporozoite invasion
BackgroundChicken coccidiosis is a parasitic disease caused by Eimeria of Apicomplexa, which has caused great economic loss to the poultry breeding...
-
Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition
PurposeGlioma has been demonstrated as one of the most malignant intracranial tumors and currently there is no effective treatment. Based on our...
-
A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host’s cell vimentin
The parasitic nematode Trichinella has a special relationship with its host as it has a unique intracellular location within the feeder cell which is...
-
Generation and Release of Neurogranin, Vimentin, and MBP Proteolytic Peptides, Following Traumatic Brain Injury
Traumatic brain injury (TBI) is a major neurological disorder without FDA-approved therapies. In this study, we have examined the concept that TBI...
-
High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors
BackgroundPancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms with malignant behaviors that can develop from inert slow...
-
CMTM6 promotes migration, invasion, and EMT by interacting with and stabilizing vimentin in hepatocellular carcinoma cells
BackgroundCKLF like MARVEL transmembrane domain containing 6 (CMTM6) has been associated with the development in many kinds of cancers. However, the...
-
WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer
BackgroundWD40 repeat (WDR)43 is an RNA-binding protein that belongs to the WDR domain protein family. Its biological function is largely unclear,...
-
Interaction between cadherins, vimentin, and V-set and immunoglobulin domain containing 1 in gastric-type hepatocellular carcinoma
In hepatocellular carcinomas (HCCs), the role of the cell surface protein V-set and immunoglobulin domain containing 1 (VSIG1), which is known as a...
-
MicroRNA-146a suppresses tumor malignancy via targeting vimentin in esophageal squamous cell carcinoma cells with lower fibronectin membrane assembly
BackgroundEsophageal squamous cell carcinoma (ESCC) is widely prevalent in Taiwan, and high metastatic spread of ESCC leads to poor survival rate....
