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Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis
The primate hippocampus includes the dentate gyrus, cornu ammonis (CA), and subiculum. CA is subdivided into four fields (CA1-CA3, plus CA3h/hilus of...
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An acute bout of resistance exercise increases BDNF in hippocampus and restores the long-term memory of insulin-resistant rats
A sedentary lifestyle, inadequate diet, and obesity are substantial risk factors for Type 2 diabetes mellitus (T2DM) development. A major picture of...
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Neural Correlates of Spatial Navigation in Primate Hippocampus
The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that...
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Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring
BackgroundChildren born to obese mothers are at increased risk of developing mood disorders and cognitive impairment. Experimental studies have...
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DNA Methylation Description of Hippocampus, Cortex, Amygdala, and Blood of Drug-Resistant Temporal Lobe Epilepsy
Epigenetic changes such as DNA methylation were observed in drug-resistant temporal lobe epilepsy (DR-TLE), a disease that affects 25–30% of epilepsy...
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Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice
The early stages of ageing are a critical time window in which the ability to detect and identify precocious molecular and cognitive markers can make...
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Alteration of Glycerophospholipid Metabolism in Hippocampus of Post-stroke Depression Rats
Post-stroke depression (PSD) is the most common mental disorder in stroke survivors. However, its specific pathophysiology remains largely unknown....
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Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Developing Defects in Down Syndrome
Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy of all or part of chromosome 21. Competing endogenous RNAs...
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Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus
Recent evidence indicates that ultraviolet (UV) exposure of the skin can affect brain functions such as learning and memory, addictive behavior, and...
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Neural dynamics underlying associative learning in the dorsal and ventral hippocampus
Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how...
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Neural representation of human experimenters in the bat hippocampus
Here we conducted wireless electrophysiological recording of hippocampal neurons from Egyptian fruit bats in the presence of human experimenters. In...
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Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats
The objective of this study was to evaluate the combined and independent effects of exercise training and L-Arginine loaded chitosan nanoparticles...
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Transcerebral information coordination in directional hippocampus-prefrontal cortex network during working memory based on bimodal neural electrical signals
Working memory (WM) is a kind of advanced cognitive function, which requires the participation and cooperation of multiple brain regions. Hippocampus...
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Preventive Effect of Betaine Against Cognitive Impairments in Amyloid β Peptide-Injected Mice Through Sirtuin1 in Hippocampus
In the pathophysiology of Alzheimer’s disease, the deposition of amyloid β peptide (Aβ) is associated with oxidative stress, leading to cognitive...
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Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation
BackgroundAbnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD)....
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Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning
Hippocampal afferent inputs, terminating on proximal and distal subfields of the cornus ammonis (CA), enable the functional discrimination of ‘what’...
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S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats
Clinical studies have found that ketamine has a rapid and lasting antidepressant effect, especially in the case of patients with major depressive...
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Protective Effect of Nerve Growth Factor in the Hippocampus against Disturbances in Synaptic Plasticity Caused by Cholinergic Deficit
Abstract —We studied the effect of nerve growth factor NGF on the plasticity of synapses formed by Schaffer collaterals on hippocampal CA1 neurons...
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Neuroplastic Changes in the Superior Colliculus and Hippocampus in Self-rewarding Paradigm: Importance of Visual Cues
Coincident excitation via different sensory modalities encoding objects of positive salience is known to facilitate learning and memory. With a view...
