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YAP1/Piezo1 involve in the dynamic changes of lymphatic vessels in UVR-induced photoaging progress to squamous cell carcinoma
BackgroundUV-induced cutaneous squamous cell carcinoma (cSCC) is one of the most common skin cancers. The constant alterations of the...
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The Role of Changes in the Expression of Inflammation-Associated Genes in Cerebral Small Vessel Disease with Cognitive Impairments
Objectives . To clarify the role of changes in the expression of inflammation-associated genes in cerebral small vessel disease (cSVD). Materials and...
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PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation
BackgroundPhosphatase and tensin homolog (PTEN) is a tumor suppressor. Low PTEN expression has been observed in pancreatic neuroendocrine tumors...
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Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context
The lymphatic vasculature mediates essential physiological functions including fluid homeostasis, lipid and hormone transport, and immune cell...
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Explicate molecular landscape of combined pulmonary fibrosis and emphysema through explainable artificial intelligence: a comprehensive analysis of ILD and COPD interactions using RNA from whole lung homogenates
Combined pulmonary fibrosis and emphysema (CPFE) presents a unique challenge in respiratory disorders, merging features of interstitial lung disease...
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Genetics of myocardial interstitial fibrosis in the human heart and association with disease
Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse prognosis. Here, to investigate the biological pathways that...
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The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk
Vegfc/Vegfr3 signaling is critical for lymphangiogenesis, the sprouting of lymphatic vessels. In zebrafish, cells sprouting from the posterior...
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Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma
BackgroundDespite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of...
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A predictive model for assessing prognostic risks in gastric cancer patients using gene expression and methylation data
BackgroundThe role(s) of epigenetic reprogramming in gastric cancer (GC) remain obscure. This study was designed to identify methylated gene markers...
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Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose
BackgroundPeritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.
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Lymphatic vessels in the age of cancer immunotherapy
Lymphatic transport maintains homeostatic health and is necessary for immune surveillance, and yet lymphatic growth is often associated with solid...
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Potential functions of embryonic cardiac macrophages in angiogenesis, lymphangiogenesis and extracellular matrix remodeling
The role of cardiac tissue macrophages (cTMs) during pre- and postnatal developmental stages remains in many aspects unknown. We aimed to...
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Mesenteric Organ Lymphatics in Abdominal Inflammation
The understanding of the lymphatic vasculature lags far behind that of the blood vasculature, despite both belonging to vascular circulatory systems....
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Molecular mechanism of anticancer effect of heat shock protein 90 inhibitor BIIB021 in human bladder cancer cell line
Bladder cancer is a type of urologic malignancy that exhibits significant morbidity, mortality, and treatment costs. Inhibition of heat shock protein...
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The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury
The osmosensitive transcription factor nuclear factor of activated T cells 5 (NFAT5; or tonicity-responsive enhancer binding protein; TonEBP) plays a...
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Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis
BackgroundThe hypoxia-responsive long non-coding RNA, RP11-367G18.1 , has recently been reported to induce histone 4 lysine 16 acetylation (H4K16Ac)...
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The Impact of VEGF-C-Induced Dural Lymphatic Vessel Growth on Ischemic Stroke Pathology
Timely relief of edema and clearance of waste products, as well as promotion of anti-inflammatory immune responses, reduce ischemic stroke pathology,...
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Expression of Vascular Endothelial Growth Factor at High Altitude
Oxygen plays an important role in aerobic respiration in mammals. However, there is subsequent decrease in partial pressure of oxygen with increase...
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Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients
BackgroundGlioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features...
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Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis
In the repair of maxillofacial bone defects, autogenous craniofacial bone can often provide superior clinical results over long bone grafts. Most...
