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Important Considerations for ELISpot Validation
The ELISpot assay has a solid place in the immune monitoring field for over 40 years. It is an assay that can assess the function of single immune...
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Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers) has intensified in recent years. Such biomarkers...
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Development and validation of a preoperative CT‑based radiomics nomogram to differentiate tuberculosis granulomas from lung adenocarcinomas: an external validation study
BackgroundAn accurate and non-invasive approach is urgently needed to distinguish tuberculosis granulomas from lung adenocarcinomas. This study aimed...
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Neutralizing Antibody Validation Testing and Reporting Harmonization
Evolving immunogenicity assay performance expectations and a lack of harmonized neutralizing antibody validation testing and reporting tools have...
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Assessing the performance of QSP models: biology as the driver for validation
Validation of a quantitative model is a critical step in establishing confidence in the model’s suitability for whatever analysis it was designed....
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Drug Target Selection and Validation
The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug...
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Development and validation of a new algorithm for improved cardiovascular risk prediction
QRISK algorithms use data from millions of people to help clinicians identify individuals at high risk of cardiovascular disease (CVD). Here, we...
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Transgenesis: In the Drug Discovery Process, Including Target Identification and Target Validation
Transgenic targeting is the most dependable method for mouse transgenesis because it produces predictable transgene expression patterns. This method...
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A bioassay method validation framework for laboratory and semi-field tests used to evaluate vector control tools
Vector control interventions play a fundamental role in the control and elimination of vector-borne diseases. The evaluation of vector control...
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Introduction to Target Validation
Although any macromolecule linked to a pathophysiological phenomenon is a natural candidate for therapeutic intervention, not all of them fulfil the...
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Development and validation of a clinical breast cancer tool for accurate prediction of recurrence
Given high costs of Oncotype DX (ODX) testing, widely used in recurrence risk assessment for early-stage breast cancer, studies have predicted ODX...
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Development and validation of explainable machine-learning models for carotid atherosclerosis early screening
BackgroundCarotid atherosclerosis (CAS), an important factor in the development of stroke, is a major public health concern. The aim of this study...
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Biomarker Assay Validation by Mass Spectrometry
Decades of discussion and publication have gone into the guidance from the scientific community and the regulatory agencies on the use and validation...
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Validation of Animal Models
Animal research provides a major contribution to the discovery of new compounds and its mechanism of action. It also deals with the pharmacokinetics...
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Development and validation of a nomogram for predicting overall survival in patients with early-onset endometrial cancer
BackgroundThis study aimed to investigate the differences in the clinicopathological characteristics of younger and older patients with endometrial...
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Bioinformatics Analysis and Experimental Validation of Differential Genes and Pathways in Bone Nonunions
Non-union fractures pose a significant clinical challenge, often leading to prolonged pain and disability. Understanding the molecular mechanisms...
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Development and validation of a nomogram for predicting overall survival in patients with sinonasal mucosal melanoma
BackgroundSinonasal mucosal melanoma (SNMM) is a relatively rare malignant tumour with a poor prognosis. This study was designed to identify...
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Development and validation of a promising 5-gene prognostic model for pediatric acute myeloid leukemia
Risk classification in pediatric acute myeloid leukemia (P-AML) is crucial for personalizing treatments. Thus, we aimed to establish a...
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Development and validation of nomogram for predicting the risk of transferring to the ICU for children with influenza
ObjectiveDevelopment of a nomogram model for predicting the magnitude of risk of transferring hospitalized children with influenza to the ICU.
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