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Tumor Suppressor Genes
Tumor suppressors are the second major type of cancer genes. In contrast to oncogenes, tumor suppressor genes have to undergo loss of function to...
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Tumor Suppressor Genes and Cell Fate Control
In this chapter, we will present the transcription factor p53, which is encoded by the most prominent cancer driver gene, the tumor suppressor gene...
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Tumor Suppressor Genes
The identification of recessive mutations that cause cancer solved the mystery of heritable cancer syndromes, and also provided a new perspective on...
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Tumor Suppressor Par-4 Structural Features, Molecular Mechanisms and Function
Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing...
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Metastasis suppressor genes and their role in the tumor microenvironment
The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within...
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Synaptopodin-2: a potential tumor suppressor
Initially identified as an actin-binding protein containing a PSD95-DLG-ZO1 Domain (PZD domain), Synaptopodin 2 (SYNPO2) has long been considered a...
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A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity
BackgroundOsteosarcoma (OS) is one of most commonly diagnosed bone cancer. Circular RNAs (circRNAs) are a class of highly stable non-coding RNA, the...
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Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas
BackgroundThe complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the...
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Nontoxic Natural Products as Regulators of Tumor Suppressor Gene Function
Cancer is a multifactorial disorder caused by the accumulation of multiple genetic, epigenetic lesions or its combination on cancer critical genes,...
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Integrative genomics identifies SHPRH as a tumor suppressor gene in lung adenocarcinoma that regulates DNA damage response
BackgroundIdentification of driver mutations and development of targeted therapies has considerably improved outcomes for lung cancer patients....
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Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products
During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is...
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Identification of FOXP1 as a favorable prognostic biomarker and tumor suppressor in intrahepatic cholangiocarcinoma
BackgroundForkhead-box protein P1 (FOXP1) has been proposed to have both oncogenic and tumor-suppressive properties, depending on tumor...
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KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers?
Present therapeutic approaches do not effectively target metastatic cancers, often limited by their inability to eliminate already-seeded...
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Loss of tumor suppressor menin expression in high grade cholangiocarcinomas
BackgroundMEN1 , which codes for the protein menin, is a tumor suppressor in neuroendocrine tissue. In cholangiocarcinoma (CCA) cell lines the...
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Role of myeloid-derived suppressor cells in tumor recurrence
The establishment of primary tumor cells in distant organs, termed metastasis, is the principal cause of cancer mortality and is a crucial...
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Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation
The natural product Honokiol exhibits robust antitumor activity against a range of cancers, and it has also received approval to undergo phase I...
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Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
Glioblastomas derived from malignant astrocytes are the most common primary tumors of the central nervous system in humans, exhibiting very bad...
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Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs
BackgroundFibroblast growth factor receptor (FGFR) gene family alterations are found in several cancers, indicating their importance as potential...
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Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma
BackgroundEpigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted...
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RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid
BackgroundIncreasing evidence proves that RBP7 plays a significant role in breast cancer (BC). The present study was aimed to investigate the...
