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Tumor Microenvironment
In this chapter, we will learn that the tumor microenvironment is a stroma of normal cells supporting cancer cells. Tumors act like parasites that...
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Introduction to Tumor Microenvironment
The knowledge of tumor microenvironment (TME) has grown exponentially in recent decades. TME is a complex milieu with an essential role in tumor...
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Tumor Microenvironment: Multiway Role in Drug Resistance
The tumor microenvironment (TME) is an ecosystem that surrounds a tumor inside the body. TME contains a complex and dynamic system that consists of...
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Tumor Microenvironment and Tumor-Targeted Therapy
Cancer tissue or cancer cells do not exist in isolation, but start life within the microenvironment called tumor microenvironment (TME). The...
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The Tumor Microenvironment Methods and Protocols
This second edition provides update and new chapters detailing core and emerging in vitro and in vivo protocols. Chapters guide readers through...
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Breast Tumor Microenvironment and CDKs
Breast malignancy is one of the most frequently diagnosed carcinoma in women globally, and it is also the common reason for tumor-associated fatality...
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Basic Insights into Tumor Microenvironment in Prostate Cancer
Prostate cancer, a prominent malignancy impacting men worldwide, is characterized by a dynamic and intricate interplay between cancer cells and their...
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Tumor Microenvironment-Responsive Nanoplatforms for Triggering Drug Delivery
Cancer is the second leading cause of mortality among nontransmissible diseases globally. Despite the advances in chemotherapy, the insufficient drug...
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The Tumor Microenvironment
The microenvironment of cancerous tissue consists of inflammatory cells, immune cells, blood vessels, neuroendocrine cells, myofibroblasts,...
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The immunosuppressive landscape in tumor microenvironment
Recent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer...
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Revamping Anticancer Strategies by Modulating Tumor Microenvironment Using Botanicals
The successful development and progression of cancer is dependent not only upon the growth and proliferation of transformed cells but relies equally...
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Acidity and hypoxia of tumor microenvironment, a positive interplay in extracellular vesicle release by tumor cells
The complex and continuously evolving features of the tumor microenvironment, varying between tumor histotypes, are characterized by the presence of...
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Hypoxic Tumor Microenvironment: Driver for Cancer Progression
Hypoxia or low oxygen concentration is one of the major physiological parameters within tumor microenvironment (TME). It has a profound effect in...
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Tumor Inflammatory Microenvironment in Lung Cancer: Heterogeneity and Implications
Tumor diseases continue to pose a significant global health challenge, accounting for a substantial portion of human mortality. The formation and...
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HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data
BackgroundCellular compositions of solid tumor microenvironments are heterogeneous, varying across patients and tumor types. High-resolution...
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Targeting metabolism to enhance immunotherapy within tumor microenvironment
Cancer metabolic reprogramming has been considered an emerging hallmark in tumorigenesis and the antitumor immune response. Like cancer cells, immune...
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Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heterogeneity of PDAC, coupled...
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Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment
Cancer is ranked as the deadliest prime health issue, albeit with mammoth efforts to panacea the ailment. To subdue the vast constraints in tumor...
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Biophysical Regulation of TGFβ Signaling in the Tumor Microenvironment
Transforming growth factor (TGF)-β is a multifunctional cytokine that contributes to epithelial–mesenchymal transition, tumor development, and...
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SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer
Anti-programmed cell death 1 (aPD1) therapy has yielded limited success in patients with colorectal cancer (CRC). Syndecan binding protein (SDCBP),...
