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The Gene Rearrangement and Transcriptional Regulation of Non B Cell-Derived Immunoglobulin
Traditionally, immunoglobulin (Ig) expression has been attributed solely to B cells/plasma cells with well-documented and accepted regulatory...
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MicroRNAs and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV
Human immunodeficiency virus (HIV) and human T cell leukemia virus (HTLV) have replicative and latent stages of infection. The status of the viruses...
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Transcriptional regulation of Tfh dynamics and the formation of immunological synapses
Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark...
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Transcriptional regulation of cancer stem cell: regulatory factors elucidation and cancer treatment strategies
Cancer stem cells (CSCs) were first discovered in the 1990s, revealing the mysteries of cancer origin, migration, recurrence and drug-resistance from...
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Post-transcriptional Gene Regulation During Cortical Development
Higher-order cognitive function in mammals is derived from the activity of the cerebral cortex. This brain structure is among the most complex...
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Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy
Cancer cells largely rely on aerobic glycolysis or the Warburg effect to generate essential biomolecules and energy for their rapid growth. The key...
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Post-transcriptional Gene Regulation During Cortical Development
Higher-order cognitive function in mammals is derived from the activity of the cerebral cortex. This brain structure is among the most complex...
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NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells
BackgroundMultiple genetic and epigenetic regulatory mechanisms are crucial in the development and tumorigenesis process. Transcriptional regulation...
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Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages
Accumulating evidence hints heterochromatin anchoring to the inner nuclear membrane as an upstream regulatory process of gene expression. Given that...
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Histone Demethylase KDM3 (JMJD1) in Transcriptional Regulation and Cancer Progression
Methylation of histone H3 lysine 9 (H3K9) is a repressive histone mark and associated with inhibition of gene expression. KDM3 is a subfamily of the...
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Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and a displaced single-stranded DNA, that frequently form...
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Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
BackgroundFollowing solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a...
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Transcriptional regulation of Glis2 in hepatic fibrosis
The role of Gli-similar 2 (Glis2) in hepatic fibrosis (HF) is controversial. In this study, we focused on the functional and molecular mechanisms...
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Transcriptional regulation and chromatin dynamics at DNA double-strand breaks
In eukaryotic cells, DNA damage can occur at any time and at any chromatin locus, including loci at which active transcription is taking place. DNA...
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Bioinformatic Analysis Reveals the Association of Human N-Terminal Acetyltransferase Complexes with Distinct Transcriptional and Post-Transcriptional Processes
N-terminal acetyltransferases (NAT) are the protein complexes that deposit the abundant N-terminal acetylation (Nt-Ac) on eukaryotic proteins, with...
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Emerging insights into transcriptional condensates
Eukaryotic transcription, a fundamental process that governs cell-specific gene expression, has long been the subject of extensive investigations in...
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Basal Transcriptional Machinery
In this chapter, we will discuss the impact of TSS regions, which are also known as core promoters. This is a prerequisite for understanding how...
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Mechanisms of ion transport regulation by HNF1β in the kidney: beyond transcriptional regulation of channels and transporters
Hepatocyte nuclear factor 1β (HNF1β) is a transcription factor essential for the development and function of the kidney. Mutations in and deletions...
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A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation
Bovine Leukemia Virus (BLV) is the etiological agent of enzootic bovine leukosis, a disease characterized by the neoplastic proliferation of B cells...
