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Levosimendan inhibits disulfide tau oligomerization and ameliorates tau pathology in TauP301L-BiFC mice
Tau oligomers play critical roles in tau pathology and are responsible for neuronal cell death and transmitting the disease in the brain....
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Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice
Accumulation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau is a histopathological hallmark of Alzheimer’s disease (AD) and...
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TDP-43 pathology is associated with increased tau burdens and seeding
BackgroundMost Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC),...
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LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
BackgroundMutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate...
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Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
The cholinesterase inhibitor donepezil is used to improve Aβ pathology and cognitive function in patients with Alzheimer’s disease (AD). However, the...
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Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
Tauopathies are neurodegenerative diseases that typically require postmortem examination for a definitive diagnosis. Detecting neurotoxic tau...
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Accurate digital quantification of tau pathology in progressive supranuclear palsy
The development of novel treatments for Progressive Supranuclear Palsy (PSP) is hindered by a knowledge gap of the impact of neurodegenerative...
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Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
Tau deposits in astrocytes are frequently found in Alzheimer’s disease (AD) and other tauopathies. Since astrocytes do not express tau, the...
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The Spectrum of Tau Pathology in Human Prion Disease
Intracellular deposition of hyperphosphorylated tau characterizes tauopathies: there is a spectrum from neuron-predominant through mixed neuronal and...
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ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study
BackgroundIt has been reported that the risk of Alzheimer’s disease (AD) could be predicted by the Australian National University Alzheimer Disease...
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Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration
Abnormal posttranslational modifications of tau play important roles in mediating neurodegeneration in tauopathies including Alzheimer’s disease....
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Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
An unresolved question for the understanding of Alzheimer’s disease (AD) pathophysiology is why a significant percentage of amyloid-β (Aβ)-positive...
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The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
Apolipoprotein E4 ( APOE4 ) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD), leading to earlier age of clinical onset...
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Tau Pathology in Neurodegenerative Diseases
Aggregation and cellular accumulation of tau protein is a defining feature of tauopathies, a class of histopathologically and clinically...
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Granulovacuolar degeneration bodies are independently induced by tau and α-synuclein pathology
BackgroundGranulovacuolar degeneration bodies (GVBs) are intracellular vesicular structures that commonly accompany pathological tau accumulations in...
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CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease
Aggregated insoluble tau is one of two defining features of Alzheimer’s disease. Because clinical symptoms are strongly correlated with tau...
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Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
BackgroundAlzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau...
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Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy
BackgroundChronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by hyperphosphorylated tau (p-tau) accumulation. The...
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Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology
Proteasomal degradation of intrinsically disordered proteins, such as tau, is a critical component of proteostasis in both aging and...
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Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells
In Alzheimer disease (AD), Tau, an axonal microtubule-associated protein, becomes hyperphosphorylated, detaches from microtubules, accumulates, and...
