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Target enrichment long-read sequencing with adaptive sampling can determine the structure of the small supernumerary marker chromosomes
Structural analysis of small supernumerary marker chromosomes (sSMCs) has revealed that many have complex structures. Structural analysis of sSMCs by...
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Enrichment strategies to enhance genome editing
Genome editing technologies hold great promise for numerous applications including the understanding of cellular and disease mechanisms and the...
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RepEnTools: an automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats
BackgroundRepeat elements (REs) play important roles for cell function in health and disease. However, RE enrichment analysis in short-read...
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ECNano: A cost-effective workflow for target enrichment sequencing and accurate variant calling on 4800 clinically significant genes using a single MinION flowcell
BackgroundThe application of long-read sequencing using the Oxford Nanopore Technologies (ONT) MinION sequencer is getting more diverse in the...
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Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment
In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through accurate assessment of minimal residual disease (MRD) and...
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Target-Captured mRNA from Murine Olfactory Bulb
The external world is perceived via sensory receptors arranged in highly organized systems according to functional strategies, which in turn reflect...
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Transgenesis: In the Drug Discovery Process, Including Target Identification and Target Validation
Transgenic targeting is the most dependable method for mouse transgenesis because it produces predictable transgene expression patterns. This method...
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Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels
Recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for...
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Method for the Enrichment of N6-Methyladenosine-Modified Cellular and HIV-1 RNA
N6-methyladenosine (m6A) modification of RNA is an important area in studying viral replication, cellular responses, and host immunity. HIV-1 RNA...
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In silico analysis of prognostic and diagnostic significance of target genes from prostate cancer cell lines derived exomicroRNAs
BackgroundCancer-secreted exovesicles are important for cell-to-cell communication by altering cancer-related signalling pathways....
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Minor Allele Enrichment in Liquid Biopsies Using Nuclease-Assisted Elimination of Wild-Type DNA
Circulating DNA analysis presents opportunities in harnessing the potential of tumor biomarkers in a minimally invasive manner but also presents...
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CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research
BackgroundPathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways....
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Revealing Prdx4 as a potential diagnostic and therapeutic target for acute pancreatitis based on machine learning analysis
Acute pancreatitis (AP) is a common systemic inflammatory disease resulting from the activation of trypsinogen by various incentives in ICU. The...
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Assessing the efficacy of target adaptive sampling long-read sequencing through hereditary cancer patient genomes
Innovations in sequencing technology have led to the discovery of novel mutations that cause inherited diseases. However, many patients with...
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Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer
BackgroundHistone lysine lactylation ( Kla ) is a newly identified histone modification, which plays a crucial role in cancer progression. Hence, we...
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Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche
Immunotherapies with antibody–drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize...
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A comparison of the chemo- and radiotoxicity of thorium and uranium at different enrichment grades
Uranium and thorium are heavy metals, and all of their isotopes are radioactive, so it is impossible to study chemical effects entirely independent...
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A novel target enrichment strategy in next-generation sequencing through 7-deaza-dGTP-resistant enzymatic digestion
ObjectiveOwing to the overwhelming dominance of human and commensal microbe sequences, low efficiency is a major concern in clinical viral sequencing...
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The target atlas for antibody-drug conjugates across solid cancers
Antibody-Drug Conjugates (ADCs) represent a rapidly advancing category of oncology therapeutics, spanning the targeted therapy for both hematologic...
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Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer
BackgroundThe origin recognition complex 1 (ORC1) is a large subunit of the origin recognition complex and acts as the master subunit of the...
