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Social isolation leads to mild social recognition impairment and losses in brain cellularity
Chronic social stress is a significant risk factor for several neuropsychiatric disorders, mainly major depressive disorder (MDD). In this way,...
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Social isolation and the risk of Parkinson disease in the UK biobank study
Parkinson disease (PD) has become one of the most rapidly growing causes of disability among the older population and social isolation is a major...
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Oxytocin and Social Isolation: Nonapeptide Regulation of Social Homeostasis
Social isolation imposes physiological and behavioural effects that can have a severe impact on health, but the underlying mechanisms remain poorly...
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Increased social interaction in Shank2-deficient mice following acute social isolation
Autism spectrum disorder (ASD) is neuropsychiatric disorder with a gender specific risk. Although social impairment in ASD is one of the well...
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Impaired Cognitive Functions in Prolonged Social Isolation: Results of Human Studies and Animal Experiments
Close social connections are essential for mental and physical health and well-being at any age. A significant proportion of the world’s population...
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Homocysteine Modulates Social Isolation–Induced Depressive-Like Behaviors Through BDNF in Aged Mice
Social isolation is an unpleasant experience associated with an increased risk of mental disorders. Exploring whether these experiences affect...
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Changes in Sociability and Preference for Social Novelty in Female Rats in Prolonged Social Isolation
Chronic stress due to social isolation (SI) can lead to distress with negative consequences for both humans and animals. Numerous disorders caused by...
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Environmental enrichment reverses proulcerogenic action of social isolation on the gastric mucosa and positively influences pain sensitivity and work capacity
The aim of the study was to investigate the effects of rat housing conditions—standard conditions, social isolation, environmental enrichment—and the...
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Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats
Rationale and ObjectiveDeprivation of social interaction promotes social reward seeking in rodents, assessed primarily by the conditioned place...
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Age-dependent effects of social isolation on mesolimbic dopamine release
In humans, social isolation is a known risk factor for disorders such as substance use disorder and depression. In rodents, social isolation is a...
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Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats
Social isolation is a state of lack of social connections, involving the modulation of different molecular signalling cascades and associated with...
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Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals
This review describes the role of social isolation in the development of anxiety and depression-like behavior in rodents. The duration of social...
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Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels
Recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for...
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The contribution of social isolation and loneliness to sleep disturbances among older adults: a systematic review
A large number of older people encounter both objective and subjective types of social isolation and sleep disorders. Social isolation increases a...
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Periadolescent Social Isolation Effects on Extinction of Conditioned Fear
Not all who are trauma-exposed develop posttraumatic stress disorder (PTSD). An important feature in its emergence is adverse early-life experiences,...
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Effects of Social Isolation and an Enriched Environment on Anxious-Depressive Behavior in Rats in Normal Conditions and after Early Proinflammatory Stress
The effects of being housed in different conditions (standard, social isolation, short periods in an enriched environment) from age 1.5 months to age...
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Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them
BackgroundAnxiety disorders are the most prevalent mental illnesses in the U.S. and are estimated to consume one-third of the country’s mental health...
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The effect of adolescent social isolation on vulnerability for methamphetamine addiction behaviours in female rats
RationaleStress exposure during adolescence contributes to developing a methamphetamine (METH) use disorder. However, most of the studies...
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Effects of Early Social Isolation on Locomotor Activity and Learning Ability in Adult WAG/Rij Rats
WAG/Rij rats, which are genetically predisposed to absence epilepsy and are characterized by a depressive state, were used for studies of the effects...
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Involvement of purinergic P2Y1R in antidepressant-like effects of electroacupuncture treatment on social isolation stress mice
Depression is a common neuropsychiatric disorder with high incidence and disability. Electroacupuncture (EA) is effective in the treatment of...
