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Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Approximately, around 2% to 3% percent of the general population experience...
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MMP-9 and TIMP-1 Levels in Children and Adolescents with Obsessive Compulsive Disorder
AbstractThis study aimed to evaluate matrix metalloproteinase-9(MMP-9), tissue inhibitors of matrix metalloproteinases (TIMP-1) and the ratio of...
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Nutritional Deficiencies in Obsessive-Compulsive Disorder and Possible Treatment Interventions
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by intrusive distressing thoughts, images, or impulses (obsessions)...
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Pharmacogenetics of Obsessive-Compulsive Disorder: An Evidence-Update
Pharmacogenetics has become increasingly important in the treatment of psychiatric disorders because approximately 50% of individuals who take...
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Inflammation, Obsessive-Compulsive Disorder, and Related Disorders
Initial reports supporting the possibility of inflammation in the brain in obsessive-compulsive disorder (OCD) evolved from the models of Sydenham’s...
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Innovations in the Delivery of Exposure and Response Prevention for Obsessive-Compulsive Disorder
Obsessive-Compulsive Disorder is an important cause of global health-related disability. In the last several decades, exposure and response...
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Psilocybin for the Treatment of Obsessive-Compulsive Disorders
Obsessive-compulsive disorder (OCD) is a highly prevalent and disabling condition for which currently available treatments are insufficiently...
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SSRIs in the Treatment of Depression: A Pharmacological CUL-DE-SAC?
The widespread adoption of selective serotonin reuptake inhibitors (SSRIs) as first-line pharmacological treatments in the management of clinical...
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Clozapine generates obsessive compulsive disorder-like behavior in mice
Clozapine is thought to induce obsessive compulsive symptoms (OCS) in schizophrenic patients. However, because OCS are often comorbid with...
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Glutamate Function in Anxiety Disorders and OCD: Evidence from Clinical and Translational Studies
Anxiety disorders affect a significant number of the world population. They are among the most prevalent disorders in society and impose enormous...
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Enhancing Fear Extinction: Pharmacological Approaches
Extinction is the process by which the memory of a learned conditioned association decreases over time and with introduction of new associations. It...
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Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder
RationaleObsessive-compulsive disorder (OCD) is characterized by repetitive behaviors exacerbated by stress. Many OCD patients do not respond to...
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Anti-Inflammatory Therapy as a Promising Target in Neuropsychiatric Disorders
This chapter analyzes the therapeutic potential of current anti-inflammatory drugs in treating psychiatric diseases from a neuro-immunological...
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St. Johnʼs wort (Hypericum perforatum) and depression: what happens to the neurotransmitter systems?
St. Johnʼs wort ( Hypericum perforatum ) is a herbaceous plant containing many bioactive molecules including naphthodianthrones, phloroglucinol...
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Pharmacotherapeutic Strategies and New Targets in OCD
Effective pharmacological and psychotherapeutic treatments are well established for obsessive-compulsive disorder (OCD). Serotonin reuptake...
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Cannabidiol for the treatment of autism spectrum disorder: hope or hype?
RationaleAutism spectrum disorder (ASD) is defined as a group of neurodevelopmental disorders whose symptoms include impaired communication and...
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The Role of the Glutamate System in Posttraumatic Stress Disorder and Glutamate-Based Treatments
Posttraumatic Stress Disorder (PTSD) is a chronic mental illness with limited options for treatment, characterized by intrusive memory of trauma,...
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Drugs Acting on Central Nervous System
Central nervous system is the part of the body which is responsible for accepting, processing, and creating response against the external stimuli or...
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Pharmacotherapy of Depression and Anxiety Disorders
Depression and anxiety are mental disorders that are difficult to diagnose and even more difficult to treat. While pharmacotherapy is one strong...
