Search
Search Results
-
Sepsis-trained macrophages promote antitumoral tissue-resident T cells
Sepsis induces immune alterations, which last for months after the resolution of illness. The effect of this immunological reprogramming on the risk...
-
The pathophysiology of sepsis and precision-medicine-based immunotherapy
Sepsis remains a major cause of morbidity and mortality in both low- and high-income countries. Antibiotic therapy and supportive care have...
-
Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology
BackgroundGut microbiota alterations have been implicated in sepsis and related infectious diseases, but the causal relationship and underlying...
-
Presepsin is a more useful predictor of septic AKI and ARDS for very-old sepsis patients than for young sepsis patients in ICUs: a pilot study
ObjectiveSepsis is a syndrome of life-threatening organ dysfunction. This study aimed to determine whether presepsin is a useful predictor of septic...
-
Galectin-3 Mediates Endotoxin Internalization and Caspase-4/11 Activation in Tubular Epithelials and Macrophages During Sepsis and Sepsis-Associated Acute Kidney Injury
Besides being recognized by membrane receptor TLR4, lipopolysaccharide (LPS) can also be internalized into the cytosol and activate Caspase-4/11...
-
A pairwise cytokine code explains the organism-wide response to sepsis
Sepsis is a systemic response to infection with life-threatening consequences. Our understanding of the molecular and cellular impact of sepsis...
-
Single-cell landscape of immunological responses in elderly patients with sepsis
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a...
-
Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis
Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is linked to a significant...
-
HDL and Sepsis
Sepsis has been recognized as a global health burden in the year 2017 for its high morbidity and mortality. HDL, a cholesterol transporter, also...
-
Identification of RRM2 as a key ferroptosis-related gene in sepsis
ObjectiveSepsis and sepsis-associated organ failure are devastating conditions for which there are no effective therapeutic agent. Several studies...
-
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
BackgroundSepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration,...
-
STAT3-Mediated Ferroptosis is Involved in Sepsis-Associated Acute Respiratory Distress Syndrome
Sepsis-induced acute respiratory distress syndrome (ARDS) poses a grave danger to life, resulting from sepsis-induced multi-organ failure. Although...
-
Blood virome of patients with traumatic sepsis
Sepsis is one of the possible outcomes of severe trauma, and it poses a dire threat to human life, particularly in immunocompromised people. The most...
-
Biomarkers of Sepsis and a Focus on PCSK9
Sepsis is a time-dependent disease and a prompt diagnosis and treatment may improve the outcome. In the actuality, we do not have a reliable...
-
Identification of four mitochondria-related genes in sepsis based on RNA sequencing technology
ObjectivesThe purpose of this study was to identify and analyze the mitochondrial genes associated with sepsis patients in order to elucidate the...
-
Neutrophils disrupt B-1a cell homeostasis by targeting Siglec-G to exacerbate sepsis
B-1a cells, an innate-like cell population, are crucial for pathogen defense and the regulation of inflammation through their release of natural IgM...
-
Pediatric sepsis inflammatory blood biomarkers that correlate with clinical variables and severity of illness scores
BackgroundSepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in...
-
Sepsis Methods and Protocols
This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease...
-
Resolving neutrophils due to TRAM deletion renders protection against experimental sepsis
ObjectiveProper inflammation resolution is crucial to prevent runaway inflammation during sepsis and reduce sepsis-related mortality/morbidity....
-
Identification of sepsis-associated mitochondrial genes through RNA and single-cell sequencing approaches
BackgroundSepsis ranks among the most formidable clinical challenges, characterized by exorbitant treatment costs and substantial demands on...
